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    Tsga10 testis specific 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252923, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tsga10provided by RGD
    Official Full Name
    testis specific 10provided by RGD
    Primary source
    RGD:621142
    See related
    Ensembl:ENSRNOG00000058681 AllianceGenome:RGD:621142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables structural molecule activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell projection assembly. Located in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 26. Orthologous to human TSGA10 (testis specific 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 210.7), Brain (RPKM 53.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tsga10 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47487007..47594201, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39991203..40098259, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44351655..44456576, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CRACD like Neighboring gene uncharacterized LOC134480567 Neighboring gene U2 spliceosomal RNA Neighboring gene chromosome 9 C2orf15 homolog Neighboring gene lipoyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Tsga10 sperm tail protein in embryogenesis and neural development: from cilium to cell division. Behnam B, et al. Biochem Biophys Res Commun, 2006 Jun 16. PMID 16643851
    2. Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein. Modarressi MH, et al. Biol Reprod, 2004 Mar. PMID 14585816, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116360

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific gene 10 protein
    Names
    cp431

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393709.1 → NP_001380638.1  testis-specific gene 10 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6A5V1, B4F7B1
      Related
      ENSRNOP00000086447.1, ENSRNOT00000094020.1
      Conserved Domains (2) summary
      COG1196
      Location:140 → 504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:412 → 615
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47487007..47594201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266681.1 → XP_063122751.1  testis-specific gene 10 protein isoform X11

      UniProtKB/TrEMBL
      A0A8I6A2Q7

    2. XM_063266679.1 → XP_063122749.1  testis-specific gene 10 protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6A5V1, B4F7B1

    3. XM_063266671.1 → XP_063122741.1  testis-specific gene 10 protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5YC11

    4. XM_063266675.1 → XP_063122745.1  testis-specific gene 10 protein isoform X6

      UniProtKB/TrEMBL
      A0A8I5YC11

    5. XM_063266673.1 → XP_063122743.1  testis-specific gene 10 protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2JT84, A0A8I5YC11

    6. XM_063266680.1 → XP_063122750.1  testis-specific gene 10 protein isoform X10

      UniProtKB/TrEMBL
      A0A8I6A2Q7

    7. XM_063266674.1 → XP_063122744.1  testis-specific gene 10 protein isoform X5

      UniProtKB/TrEMBL
      A0A8I5YC11

    8. XM_063266677.1 → XP_063122747.1  testis-specific gene 10 protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A5V1

    9. XM_063266670.1 → XP_063122740.1  testis-specific gene 10 protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5YC11

    10. XM_063266678.1 → XP_063122748.1  testis-specific gene 10 protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6A5V1

    11. XM_063266672.1 → XP_063122742.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5YC11

    12. XM_063266676.1 → XP_063122746.1  testis-specific gene 10 protein isoform X7

      UniProtKB/TrEMBL
      A0A8I5YC11

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001030022.1: Suppressed sequence

      Description
      NM_001030022.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z220.2 GenPept UniProtKB/Swiss-Prot:Q9Z220

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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