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    MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 51275, updated on 10-Oct-2023

    Summary

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    Official Symbol
    MAPKAPK5-AS1provided by HGNC
    Official Full Name
    MAPKAPK5 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:24091
    See related
    Ensembl:ENSG00000234608 AllianceGenome:HGNC:24091
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAAS; C12orf47
    Expression
    Ubiquitous expression in colon (RPKM 6.8), lymph node (RPKM 5.9) and 25 other tissues See more
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    Genomic context

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    Location:
    12q24.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (111839767..111843005, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (111816678..111819916, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112277571..112280809, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112123487-112124188 Neighboring gene acyl-CoA dehydrogenase family member 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112194124-112194765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112195407-112196048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112196049-112196688 Neighboring gene NANOG hESC enhancer GRCh37_chr12:112199468-112200003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112204196-112204965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112210937-112211508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7039 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112228790-112229715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112229716-112230640 Neighboring gene microRNA 6761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112272338-112273217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7041 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112282209-112282377 Neighboring gene MAPK activated protein kinase 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112292092-112292249 Neighboring gene ribosomal protein S2 pseudogene 41 Neighboring gene ADAM metallopeptidase domain 1A (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma. Tao L, et al. Lab Invest, 2022 May. PMID 35264707
    2. IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH. Zhou Y, et al. Eur J Histochem, 2020 Dec 3. PMID 33272009, Free PMC Article
    3. Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge. Yang T, et al. J Exp Clin Cancer Res, 2020 Jul 20. PMID 32690100, Free PMC Article
    4. lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Wen J, et al. FEBS Open Bio, 2020 Aug. PMID 32569434, Free PMC Article
    5. LncRNA-cCSC1 modulates cancer stem cell properties in colorectal cancer via activation of the Hedgehog signaling pathway. Zhou H, et al. J Cell Biochem, 2020 Mar. PMID 31680315

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma.
      Title: Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma.
    2. Upregulation of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in non-functioning pituitary adenoma.
      Title: Upregulation of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in non-functioning pituitary adenoma.
    3. LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma.
      Title: LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma.
    4. lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
      Title: lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
    5. LncRNA-cCSC1 promotes cell proliferation of colorectal cancer through sponging miR-124-3p and upregulating CD44.
      Title: LncRNA-cCSC1 promotes cell proliferation of colorectal cancer through sponging miR-124-3p and upregulating CD44.
    6. IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH.
      Title: IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH.
    7. Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.
      Title: Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge.
    8. Data show that cyclin-dependent kinase inhibitor 1A protein (p21) is a target of long noncoding RNA MAPKAPK5-AS1.
      Title: Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer proliferation by partly silencing p21 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • MAPKAPK5 antisense RNA 1 (non-protein coding)
    • apoptosis-related protein PNAS-1
    • lncRNA-cCSC1

    Clone Names

    • FLJ39616, AC003029.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015404.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003029, AK096935, BC071748, JQ794500
      Related
      ENST00000428207.4

    2. NR_152605.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003029, BC107695
      Related
      ENST00000692189.2

    3. NR_152606.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003029, BC032560, BC107695

    4. NR_152607.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003029, BC007973, BC107695
      Related
      ENST00000442119.7

    5. NR_152608.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003029, BC071748, BC107695
      Related
      ENST00000443596.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      111839767..111843005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      111816678..111819916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8E1.1 GenPept UniProtKB/Swiss-Prot:Q8N8E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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