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    Slco1a6 solute carrier organic anion transporter family, member 1a6 [ Mus musculus (house mouse) ]

    Gene ID: 28254, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Slco1a6provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 1a6provided by MGI
    Primary source
    MGI:MGI:1351906
    See related
    Ensembl:ENSMUSG00000079262 AllianceGenome:MGI:1351906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oatp5; Oatp-5; Slc21a13; 4930422F19Rik
    Summary
    Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Acts upstream of or within several processes, including bile acid metabolic process; heme metabolic process; and lipid homeostasis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in brain ventricle and choroid plexus; metanephros; and telencephalon ventricular layer. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward kidney adult (RPKM 11.4) See more
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    Genomic context

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    Location:
    6 G2; 6 73.42 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142031487..142131903, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142085761..142186177, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30843 Neighboring gene solute carrier organic anion transporter family, member 1a1 Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene STARR-seq mESC enhancer starr_17699 Neighboring gene STARR-seq mESC enhancer starr_17700 Neighboring gene predicted gene, 18159 Neighboring gene STARR-seq mESC enhancer starr_17701 Neighboring gene predicted gene, 53313 Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene islet amyloid polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter. Choudhuri S, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162483
    2. Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets. Tian J, et al. Genetics, 2015 Nov. PMID 26385979, Free PMC Article
    3. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. van de Steeg E, et al. J Clin Invest, 2010 Aug. PMID 20644253, Free PMC Article
    4. Molecular physiology of renal organic anion transporters. Sekine T, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403838
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that genetic variation in Slco1a6 leads to altered transport of taurocholic acid and potentially other bile acids) by pancreatic islets, resulting in broad gene regulation
      Title: Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bile acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heme metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 1A6
    Names
    kidney-specific organic anion-transporting polypeptide 5
    organic anion-transporting polypeptide
    solute carrier family (organic anion transporter) member 13
    solute carrier family 21 (organic anion transporter), member 13
    solute carrier family 21 member 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001381930.1 → NP_001368859.1  solute carrier organic anion transporter family member 1A6

      Status: VALIDATED

      Source sequence(s)
      AC134836, AK142587
      UniProtKB/Swiss-Prot
      Q3UQC6, Q99J94, Q9CUP7
      UniProtKB/TrEMBL
      Q6IR20
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    2. NM_023718.3 → NP_076207.1  solute carrier organic anion transporter family member 1A6

      See identical proteins and their annotated locations for NP_076207.1

      Status: VALIDATED

      Source sequence(s)
      AK142587, AK143970
      Consensus CDS
      CCDS39693.1
      UniProtKB/Swiss-Prot
      Q3UQC6, Q99J94, Q9CUP7
      UniProtKB/TrEMBL
      Q6IR20
      Related
      ENSMUSP00000107458.4, ENSMUST00000111827.4
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142031487..142131903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506965.3 → XP_006507028.1  solute carrier organic anion transporter family member 1A6 isoform X1

      See identical proteins and their annotated locations for XP_006507028.1

      UniProtKB/Swiss-Prot
      Q3UQC6, Q99J94, Q9CUP7
      UniProtKB/TrEMBL
      Q6IR20
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter

    2. XM_011241587.2 → XP_011239889.1  solute carrier organic anion transporter family member 1A6 isoform X1

      See identical proteins and their annotated locations for XP_011239889.1

      UniProtKB/Swiss-Prot
      Q3UQC6, Q99J94, Q9CUP7
      UniProtKB/TrEMBL
      Q6IR20
      Conserved Domains (1) summary
      TIGR00805
      Location:1 → 625
      oat; sodium-independent organic anion transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J94.1 GenPept UniProtKB/Swiss-Prot:Q99J94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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