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    RPS6KA6 ribosomal protein S6 kinase A6 [ Homo sapiens (human) ]

    Gene ID: 27330, updated on 5-May-2024

    Summary

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    Official Symbol
    RPS6KA6provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase A6provided by HGNC
    Primary source
    HGNC:HGNC:10435
    See related
    Ensembl:ENSG00000072133 MIM:300303; AllianceGenome:HGNC:10435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6
    Summary
    This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
    Expression
    Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xq21.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (84058346..84188499, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (82493471..82624675, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (83313354..83443207, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TERF1 pseudogene 4 Neighboring gene cylicin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:83239627-83240128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:83240129-83240628 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:83298980-83299480 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:83301391-83301957 Neighboring gene microRNA 548i-4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:83643706-83644905 Neighboring gene highly divergent homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma. Ma J, et al. Pathol Res Pract, 2021 Nov. PMID 34649054
    2. RSK4: a new prognostic factor in glioma. Chen L, et al. Pathol Res Pract, 2020 Aug. PMID 32703488
    3. Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma. Li MY, et al. J Clin Invest, 2020 Aug 3. PMID 32396532, Free PMC Article
    4. Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway. Mei Y, et al. J Biochem, 2020 Jun 1. PMID 31960922
    5. Effect of RSK4 on biological characteristics of colorectal cancer. Ye Q, et al. World J Surg Oncol, 2018 Dec 22. PMID 30579335, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
      Title: RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
    2. Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
      Title: Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
    3. High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
      Title: High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
    4. RSK4: a new prognostic factor in glioma.
      Title: RSK4: a new prognostic factor in glioma.
    5. Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
      Title: Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
    6. Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
      Title: Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
    7. Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
      Title: Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
    8. E2 signaling may therefore act upstream of RSK4 to promote cancer progression. The results obtained in the current study suggested that RSK4 inhibited breast cancer cell invasiveness and that RSK4 promoter hypomethylation may serve as a novel prognostic marker for patients with breast cancer.
      Title: RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer.
    9. High expression of RSK4 is associated with colorectal cancer.
      Title: Effect of RSK4 on biological characteristics of colorectal cancer.
    10. RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma.
      Title: A Pilot Study of RSK4 Expression in Patients with Human Non-Small Cell Lung Carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mesoderm development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase alpha-6
    Names
    90 kDa ribosomal protein S6 kinase 6
    S6K-alpha 6
    p90-RSK 6
    ribosomal S6 kinase 4
    ribosomal protein S6 kinase, 90kDa, polypeptide 6
    NP_001317441.1
    NP_055311.1
    XP_011529219.1
    XP_011529221.1
    XP_011529222.1
    XP_016884912.1
    XP_016884913.1
    XP_016884914.1
    XP_047297952.1
    XP_047297953.1
    XP_054182821.1
    XP_054182822.1
    XP_054182823.1
    XP_054182824.1
    XP_054182825.1
    XP_054182826.1
    XP_054182827.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016340.1 RefSeqGene

      Range
      4737..134586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330512.1 → NP_001317441.1  ribosomal protein S6 kinase alpha-6 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AL354653, AL389887, BC143648
      Consensus CDS
      CCDS83480.1
      UniProtKB/Swiss-Prot
      Q9UK32
      Conserved Domains (2) summary
      cd05582
      Location:77 → 391
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14177
      Location:421 → 715
      STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

    2. NM_014496.5 → NP_055311.1  ribosomal protein S6 kinase alpha-6 isoform 2

      See identical proteins and their annotated locations for NP_055311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but has a distinct N-terminus.
      Source sequence(s)
      AF184965, AK313240, AL354653, AL389887, BQ448025
      Consensus CDS
      CCDS14451.1
      UniProtKB/Swiss-Prot
      B2R854, B7ZL90, Q6FHX2, Q8WX28, Q9H4S6, Q9UK32
      Related
      ENSP00000262752.2, ENST00000262752.5
      Conserved Domains (2) summary
      cd05582
      Location:77 → 391
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14177
      Location:421 → 715
      STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      84058346..84188499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441997.1 → XP_047297953.1  ribosomal protein S6 kinase alpha-6 isoform X3

    2. XM_011530919.3 → XP_011529221.1  ribosomal protein S6 kinase alpha-6 isoform X4

      Conserved Domains (4) summary
      smart00220
      Location:1 → 227
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:1 → 288
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14177
      Location:318 → 612
      STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
      pfam00069
      Location:323 → 580
      Pkinase; Protein kinase domain

    3. XM_017029425.2 → XP_016884914.1  ribosomal protein S6 kinase alpha-6 isoform X1

    4. XM_047441996.1 → XP_047297952.1  ribosomal protein S6 kinase alpha-6 isoform X3

    5. XM_011530917.3 → XP_011529219.1  ribosomal protein S6 kinase alpha-6 isoform X2

      See identical proteins and their annotated locations for XP_011529219.1

      UniProtKB/Swiss-Prot
      Q9UK32
      Conserved Domains (2) summary
      cd05582
      Location:77 → 391
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14177
      Location:421 → 715
      STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

    6. XM_017029424.2 → XP_016884913.1  ribosomal protein S6 kinase alpha-6 isoform X1

    7. XM_017029423.2 → XP_016884912.1  ribosomal protein S6 kinase alpha-6 isoform X1

      Related
      ENSP00000483896.1, ENST00000620340.4

    8. XM_011530920.3 → XP_011529222.1  ribosomal protein S6 kinase alpha-6 isoform X5

      Conserved Domains (4) summary
      smart00220
      Location:1 → 209
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14177
      Location:300 → 594
      STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
      pfam00069
      Location:305 → 562
      Pkinase; Protein kinase domain
      cl21453
      Location:1 → 270
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      82493471..82624675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326851.1 → XP_054182826.1  ribosomal protein S6 kinase alpha-6 isoform X4

    2. XM_054326848.1 → XP_054182823.1  ribosomal protein S6 kinase alpha-6 isoform X1

    3. XM_054326850.1 → XP_054182825.1  ribosomal protein S6 kinase alpha-6 isoform X3

    4. XM_054326849.1 → XP_054182824.1  ribosomal protein S6 kinase alpha-6 isoform X2

    5. XM_054326847.1 → XP_054182822.1  ribosomal protein S6 kinase alpha-6 isoform X1

    6. XM_054326846.1 → XP_054182821.1  ribosomal protein S6 kinase alpha-6 isoform X1

    7. XM_054326852.1 → XP_054182827.1  ribosomal protein S6 kinase alpha-6 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK32.1 GenPept UniProtKB/Swiss-Prot:Q9UK32

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