F2R coagulation factor II thrombin receptor [Bos taurus (cattle)] - Gene

Summary

Official Symbol: F2Rprovided by VGNC
Official Full Name: coagulation factor II thrombin receptorprovided by VGNC
Primary source: VGNC:VGNC:28683
See related: BGD:BT23461; Ensembl:ENSBTAG00000020199
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PAR1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (7945904..7963559)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB
Title: Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.
PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Title: Distinct roles of protease-activated receptors in signal transduction regulation of endothelial nitric oxide synthase.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thrombin-activated receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: proteinase-activated receptor 1

Names: PAR-1; protease-activated receptor 1; thrombin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.