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    TNFAIP8L1 TNF alpha induced protein 8 like 1 [ Homo sapiens (human) ]

    Gene ID: 126282, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TNFAIP8L1provided by HGNC
    Official Full Name
    TNF alpha induced protein 8 like 1provided by HGNC
    Primary source
    HGNC:HGNC:28279
    See related
    Ensembl:ENSG00000185361 MIM:615869; AllianceGenome:HGNC:28279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIPE1
    Summary
    Enables identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver (RPKM 6.4), spleen (RPKM 5.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4639516..4655568)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4623667..4639725)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4639528..4655580)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9894 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4596181-4596372 Neighboring gene Sharpr-MPRA regulatory region 4167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4606740-4607298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4607299-4607856 Neighboring gene MPRA-validated peak3284 silencer Neighboring gene ribosomal protein S10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4639529-4640528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4660681-4661180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4661482-4662252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9901 Neighboring gene myeloid derived growth factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4675983-4676943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4679601-4680102 Neighboring gene DPP9 antisense RNA 1 Neighboring gene dipeptidyl peptidase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis. Cheng Y, et al. Cancer Res, 2022 Apr 15. PMID 35135809
    2. Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells. Bordoloi D, et al. Mol Cell Biochem, 2021 Sep. PMID 33895911
    3. TIPE1 accelerates atherogenesis by inducing endothelial dysfunction in response to oxidative stress. Shao J, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Jan 1. PMID 31672550
    4. TIPE1 suppresses the invasion and migration of breast cancer cells and inhibits epithelial-to-mesenchymal transition primarily via the ERK signaling pathway. Qiu S, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Sep 6. PMID 31559412
    5. TIPE1 promotes cervical cancer progression by repression of p53 acetylation and is associated with poor cervical cancer outcome. Zhao P, et al. Carcinogenesis, 2019 Jun 10. PMID 30445600

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A pan-cancer analysis of TNFAIP8L1 in human tumors.
      Title: A pan-cancer analysis of TNFAIP8L1 in human tumors.
    2. TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing Wnt/beta-catenin signaling.
      Title: TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing Wnt/β-catenin signaling.
    3. TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation.
      Title: TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation.
    4. Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFbeta Axis.
      Title: Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis.
    5. TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
      Title: TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
    6. TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-kappaB pro-oncogenic signaling pathway.
      Title: TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway.
    7. Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells.
      Title: Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells.
    8. TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway.
      Title: TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway.
    9. CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1.
      Title: CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1.
    10. TNFAIP8L1 and FLT1 polymorphisms alter the susceptibility to cervical cancer amongst uyghur females in China.
      Title: TNFAIP8L1 and FLT1 polymorphisms alter the susceptibility to cervical cancer amongst uyghur females in China.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39932, MGC17791

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 1
    Names
    TNF alpha-induced protein 8-like protein 1
    TNFAIP8-like protein 1
    oxidative stress-regulated gene-beta
    oxy-beta
    tumor necrosis factor, alpha induced protein 8 like 1
    tumor necrosis factor, alpha-induced protein 8-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167942.1 → NP_001161414.1  tumor necrosis factor alpha-induced protein 8-like protein 1

      See identical proteins and their annotated locations for NP_001161414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC005339, AC011498
      Consensus CDS
      CCDS12132.1
      UniProtKB/Swiss-Prot
      D6W627, Q8WVP5
      Related
      ENSP00000444215.1, ENST00000536716.1
      Conserved Domains (1) summary
      pfam05527
      Location:5 → 183
      DUF758; Domain of unknown function (DUF758)

    2. NM_152362.3 → NP_689575.2  tumor necrosis factor alpha-induced protein 8-like protein 1

      See identical proteins and their annotated locations for NP_689575.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC005339, BX282702
      Consensus CDS
      CCDS12132.1
      UniProtKB/Swiss-Prot
      D6W627, Q8WVP5
      Related
      ENSP00000331827.3, ENST00000327473.9
      Conserved Domains (1) summary
      pfam05527
      Location:5 → 183
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4639516..4655568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527680.3 → XP_011525982.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011525982.1

      UniProtKB/Swiss-Prot
      D6W627, Q8WVP5
      Conserved Domains (1) summary
      pfam05527
      Location:5 → 183
      DUF758; Domain of unknown function (DUF758)

    2. XM_005259487.4 → XP_005259544.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005259544.1

      UniProtKB/Swiss-Prot
      D6W627, Q8WVP5
      Conserved Domains (1) summary
      pfam05527
      Location:5 → 183
      DUF758; Domain of unknown function (DUF758)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4623667..4639725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319795.1 → XP_054175770.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D6W627, Q8WVP5

    2. XM_054319794.1 → XP_054175769.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D6W627, Q8WVP5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WVP5.2 GenPept UniProtKB/Swiss-Prot:Q8WVP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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