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    Eif4b eukaryotic translation initiation factor 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300253, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Eif4bprovided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4Bprovided by RGD
    Primary source
    RGD:1306479
    See related
    AllianceGenome:RGD:1306479
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in dendrite and neuronal cell body. Is active in postsynapse. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 843.3), Muscle (RPKM 839.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4b in Genome Data Viewer
    Location:
    7q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135085259..135107054)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133206637..133228436)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143679656..143701452)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 18 Neighboring gene uncharacterized LOC134479613 Neighboring gene uncharacterized LOC134479789 Neighboring gene tensin 2 Neighboring gene SPRY domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder. Jernigan CS, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2011 Aug 15. PMID 21635931, Free PMC Article
    2. Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid. Nicolini C, et al. Acta Neuropathol Commun, 2015 Jan 20. PMID 25627160, Free PMC Article
    3. Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. Eom T, et al. J Cell Biol, 2014 Oct 27. PMID 25332164, Free PMC Article
    4. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765
    5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94923

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008324.2 → NP_001008325.1  eukaryotic translation initiation factor 4B

      See identical proteins and their annotated locations for NP_001008325.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q5RKG9
      Conserved Domains (2) summary
      COG0724
      Location:83 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12402
      Location:95 → 171
      RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135085259..135107054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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