Clic2 chloride intracellular channel 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clic2provided by RGD
Official Full Name: chloride intracellular channel 2provided by RGD
Primary source: RGD:1306580
See related: Ensembl:ENSRNOG00000000728 AllianceGenome:RGD:1306580
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chloride channel activity and glutathione peroxidase activity. Predicted to be involved in chloride transport; positive regulation of binding activity; and regulation of release of sequestered calcium ion into cytosol. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome. Orthologous to human CLIC2 (chloride intracellular channel 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 383.9), Heart (RPKM 231.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (154630..169655)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (149337..164375)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (295338..310363)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
Title: Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.

Submit: New GeneRIF Correction

General gene information

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Markers

AU027664 (e-PCR)
- UniSTS:113085

D20Rhw1 (e-PCR)
- UniSTS:517837

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
NOT enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chloride intracellular channel protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009651.1 → NP_001009651.1 chloride intracellular channel protein 2

See identical proteins and their annotated locations for NP_001009651.1

Status: PROVISIONAL

Source sequence(s)

BC088182

UniProtKB/Swiss-Prot

Q5M883

UniProtKB/TrEMBL

A0A8I5ZTR1, A6KR35

Related

ENSRNOP00000000955.5, ENSRNOT00000000955.7

Conserved Domains (3) summary

TIGR00862
Location:12 → 245

O-ClC; intracellular chloride channel protein

cd10298
Location:106 → 244

GST_C_CLIC2; C-terminal, alpha helical domain of Chloride Intracellular Channel 2

cd03061
Location:9 → 99

GST_N_CLIC; GST_N family, Chloride Intracellular Channel (CLIC) subfamily; composed of CLIC1-5, p64, parchorin and similar proteins. They are auto-inserting, self-assembling intracellular anion channels involved in a wide variety of functions including regulated ...