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    Mamdc4 MAM domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 381352, updated on 9-May-2024

    Summary

    Official Symbol
    Mamdc4provided by MGI
    Official Full Name
    MAM domain containing 4provided by MGI
    Primary source
    MGI:MGI:2685841
    See related
    Ensembl:ENSMUSG00000026941 AllianceGenome:MGI:2685841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm995
    Summary
    Predicted to act upstream of or within protein transport. Predicted to be located in endosome. Orthologous to human MAMDC4 (MAM domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 4.7), limb E14.5 (RPKM 3.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2 A3; 2 17.41 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25453124..25461328, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25563115..25571316, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25404685-25404887 Neighboring gene STARR-positive B cell enhancer ABC_E11127 Neighboring gene predicted gene, 35476 Neighboring gene endothelial differentiation-related factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1582 Neighboring gene phosphohistidine phosphatase 1 Neighboring gene apical junction component 1 Neighboring gene RAB, member RAS oncogene family-like 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    apical endosomal glycoprotein
    Names
    MAM domain-containing protein 4
    probable ortholog of human apical early endosomal glycoprotein precursor (AEGP)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081199.1NP_001074668.2  apical endosomal glycoprotein precursor

      Status: PROVISIONAL

      Source sequence(s)
      AL732590
      Consensus CDS
      CCDS50531.1
      UniProtKB/Swiss-Prot
      A2AJA6, A2AJA7
      UniProtKB/TrEMBL
      D3YY20
      Related
      ENSMUSP00000092735.4, ENSMUST00000095117.10
      Conserved Domains (4) summary
      cd06263
      Location:823977
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:660817
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00112
      Location:234266
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00629
      Location:823979
      MAM; MAM domain, meprin/A5/mu

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25453124..25461328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940651.1 RNA Sequence