Wnt9b wingless-type MMTV integration site family, member 9B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt9bprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 9Bprovided by MGI
Primary source: MGI:MGI:1197020
See related: Ensembl:ENSMUSG00000018486 AllianceGenome:MGI:1197020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: clf; clf1; Wnt15; Wnt14b; wnt-15; wnt-14b
Summary: Enables co-receptor binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and kidney development. Predicted to be located in extracellular region. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; epithelium; genitourinary system; heart; and surface ectoderm. Orthologous to human WNT9B (Wnt family member 9B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 1.2), cerebellum adult (RPKM 0.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 67.47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (103618188..103666098, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103727362..103775272, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-transfection of M15 cells with Fzd5 (but no other Fzd family member) further increased the WNT9b signal to 16.8-fold and siRNA knockdown of Fzd5 reduced the signal by 52%
Title: Molecular determinants of WNT9b responsiveness in nephron progenitor cells.
Data indicate that mutations in wingless-type MMTV integration site family, member 9B protein (WNT9B) were frequently associated with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS).
Title: Mutations in WNT9B are associated with Mayer-Rokitansky-Küster-Hauser syndrome.
Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain.
Title: Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain.
Expression of Wnt9b in Six2-positive cells disrupts cell fate decisions in the kidney and the gastrointestinal tract.
Title: Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function.
Epithelial Wnt7b and Wnt9b as possible ligands of Fzd1-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the undifferentiated ureteric mesenchyme
Title: Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
Study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development.
Title: Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development.
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells
Title: Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.
wnt9b signaling regulates stem cell proliferation and differention in the developing kidney depending on the activity of the transcription factor Six2 in the responding cell.
Title: Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founder lines.
Title: Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development.
Findings show that Wnt9b, produced by the kidney collecting ducts, nonautonomously regulates morphogenesis of the developing kidney tubules.
Title: Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Associated conditions

Description	Tests
cleft lip 1 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (1) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Wnt9b (e-PCR), detects polymorphism
- UniSTS:508425

Wnt9b (e-PCR), detects polymorphism
- UniSTS:257033

Wnt9b (e-PCR), detects polymorphism
- UniSTS:508426

UniSTS:471334 (e-PCR)
- UniSTS:471334

Wnt9b (e-PCR), detects polymorphism
- UniSTS:471334

Wnt9b (e-PCR), detects polymorphism
- UniSTS:527148

Wnt9b (e-PCR), detects polymorphism
- UniSTS:497474

Wnt9b (e-PCR), detects polymorphism
- UniSTS:507328

Wnt9b (e-PCR), detects polymorphism
- UniSTS:256456

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity involved in nephron morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney rudiment formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal stem cell maintenance involved in nephron morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesonephric duct formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesonephric tubule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mesonephric tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephric tubule formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nephron tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of tube size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within uterus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Wnt-Frizzled-LRP5/6 complex	IC Inferred by Curator more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-9b

Names: protein Wnt-14b; wingless-type MMTV integration site 15; wingless-type MMTV integration site 9B; wingless-type MMTV integration site family, member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011719.4 → NP_035849.3 protein Wnt-9b precursor

See identical proteins and their annotated locations for NP_035849.3

Status: VALIDATED

Source sequence(s)

AK052708, AL596108, AL627252

Consensus CDS

CCDS25522.1

UniProtKB/Swiss-Prot

O35468, Q8VI90

UniProtKB/TrEMBL

Q2TBA6, Q8C718

Related

ENSMUSP00000018630.3, ENSMUST00000018630.3

Conserved Domains (1) summary

pfam00110
Location:62 → 358

wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

103618188..103666098 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245931.1 → XP_030101791.1 protein Wnt-9b isoform X1

Conserved Domains (1) summary

cl38924
Location:1 → 217

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family