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    Rhpn1 rhophilin, Rho GTPase binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300030, updated on 30-Mar-2024

    Summary

    Official Symbol
    Rhpn1provided by RGD
    Official Full Name
    rhophilin, Rho GTPase binding protein 1provided by RGD
    Primary source
    RGD:1305688
    See related
    Ensembl:ENSRNOG00000007597 AllianceGenome:RGD:1305688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and negative regulation of stress fiber assembly. Predicted to be located in plasma membrane. Orthologous to human RHPN1 (rhophilin Rho GTPase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 153.4), Testes (RPKM 27.6) and 3 other tissues See more
    Orthologs
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    Genomic context

    Location:
    7q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109272676..109283444)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107391948..107402713)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116738999..116749791)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene GLI family zinc finger 4 Neighboring gene DNA topoisomerase I mitochondrial Neighboring gene uncharacterized LOC134479926 Neighboring gene U6 spliceosomal RNA Neighboring gene MAF bZIP transcription factor A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305237.1NP_001292166.1  rhophilin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A096MIZ0, A6HS15
      Related
      ENSRNOP00000067928.2, ENSRNOT00000075837.3
      Conserved Domains (3) summary
      cd09248
      Location:116498
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      cd00992
      Location:519593
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00087
      Location:28112
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109272676..109283444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241901.5XP_006241963.1  rhophilin-1 isoform X2

      See identical proteins and their annotated locations for XP_006241963.1

      UniProtKB/TrEMBL
      A6HS15
      Conserved Domains (3) summary
      cd09248
      Location:116499
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      cd00992
      Location:520594
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00087
      Location:28112
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    2. XM_006241900.5XP_006241962.1  rhophilin-1 isoform X1

      See identical proteins and their annotated locations for XP_006241962.1

      UniProtKB/TrEMBL
      A6HS15
      Conserved Domains (3) summary
      cd09248
      Location:116499
      BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
      cd00992
      Location:520594
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00087
      Location:28112
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    3. XM_063263274.1XP_063119344.1  rhophilin-1 isoform X3

    4. XM_039078808.2XP_038934736.1  rhophilin-1 isoform X4

      Conserved Domains (2) summary
      cd00992
      Location:290364
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14649
      Location:3269
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains