Wdr18 WD repeat domain 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wdr18provided by RGD
Official Full Name: WD repeat domain 18provided by RGD
Primary source: RGD:1310646
See related: Ensembl:ENSRNOG00000012379 AllianceGenome:RGD:1310646
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in rRNA processing and regulation of DNA-dependent DNA replication initiation. Predicted to be located in dynein axonemal particle and nucleoplasm. Predicted to be part of Rix1 complex and nuclear pre-replicative complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 142.3), Heart (RPKM 111.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10390879..10398998, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9740245..9748041, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12561318..12569120, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dynein axonemal particle	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pre-replicative complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of rixosome complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039027.1 → NP_001034116.1 WD repeat-containing protein 18

See identical proteins and their annotated locations for NP_001034116.1

Status: PROVISIONAL

Source sequence(s)

BC099828

UniProtKB/Swiss-Prot

Q499N3

UniProtKB/TrEMBL

A6K8U2, F1LR39

Related

ENSRNOP00000016733.5, ENSRNOT00000016733.9

Conserved Domains (3) summary

sd00039
Location:84 → 119

7WD40; WD40 repeat [structural motif]

cl10011
Location:212 → 430

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl29593
Location:22 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10390879..10398998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078977.2 → XP_038934905.2 WD repeat-containing protein 18 isoform X1
XM_006240906.3 → XP_006240968.1 WD repeat-containing protein 18 isoform X3

UniProtKB/TrEMBL

A6K8U2, F1LR39

Conserved Domains (3) summary

sd00039
Location:7 → 42

7WD40; WD40 repeat [structural motif]

cl10011
Location:135 → 353

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl29593
Location:4 → 244

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_063263411.1 → XP_063119481.1 WD repeat-containing protein 18 isoform X2
XM_063263412.1 → XP_063119482.1 WD repeat-containing protein 18 isoform X4

UniProtKB/TrEMBL

A0A8I6AMB6, A6K8U3