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    Rtn4rl1 reticulon 4 receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 237847, updated on 12-May-2024

    Summary

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    Official Symbol
    Rtn4rl1provided by MGI
    Official Full Name
    reticulon 4 receptor-like 1provided by MGI
    Primary source
    MGI:MGI:2661375
    See related
    Ensembl:ENSMUSG00000045287 AllianceGenome:MGI:2661375
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngr3; Ngrh2; Ngrl2
    Summary
    Enables chondroitin sulfate binding activity and heparin binding activity. Involved in corpus callosum development and negative regulation of axon regeneration. Predicted to be located in external side of plasma membrane and membrane raft. Predicted to be anchored component of plasma membrane. Is expressed in brain; ganglia; heart; peripheral nervous system; and spinal cord. Orthologous to human RTN4RL1 (reticulon 4 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 25.5), bladder adult (RPKM 10.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rtn4rl1 in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75084819..75158595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75193993..75267769)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700016P03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7016 Neighboring gene microRNA 132 Neighboring gene candidate tumor suppressor in ovarian cancer 2 Neighboring gene STARR-seq mESC enhancer starr_29983 Neighboring gene diphthamide biosynthesis 1 Neighboring gene STARR-seq mESC enhancer starr_29985 Neighboring gene STARR-seq mESC enhancer starr_29986 Neighboring gene predicted gene, 35169 Neighboring gene predicted gene, 35117 Neighboring gene replication protein A1 Neighboring gene STARR-positive B cell enhancer ABC_E9826 Neighboring gene STARR-positive B cell enhancer ABC_E3972 Neighboring gene STARR-seq mESC enhancer starr_29990 Neighboring gene STARR-seq mESC enhancer starr_29991 Neighboring gene SET and MYND domain containing 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade F, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF. Bakhuraysah MM, et al. Sci Rep, 2021 Feb 3. PMID 33536561, Free PMC Article
    2. Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels. Zhao Y, et al. Neuron, 2017 Oct 11. PMID 29024660, Free PMC Article
    3. The nogo receptor family restricts synapse number in the developing hippocampus. Wills ZP, et al. Neuron, 2012 Feb 9. PMID 22325200, Free PMC Article
    4. Agenesis of the corpus callosum in Nogo receptor deficient mice. Yoo SW, et al. J Comp Neurol, 2017 Feb 1. PMID 27339102, Free PMC Article
    5. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. Pignot V, et al. J Neurochem, 2003 May. PMID 12694398

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Roundabout binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chondroitin sulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    reticulon-4 receptor-like 1
    Names
    nogo receptor-like 2
    nogo-66 receptor homolog 2
    nogo-66 receptor-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177708.5 → NP_808376.1  reticulon-4 receptor-like 1 precursor

      See identical proteins and their annotated locations for NP_808376.1

      Status: PROVISIONAL

      Source sequence(s)
      AK140456
      Consensus CDS
      CCDS25043.1
      UniProtKB/Swiss-Prot
      Q8K0S5
      Related
      ENSMUSP00000099572.4, ENSMUST00000102514.4
      Conserved Domains (4) summary
      cd00116
      Location:102 → 255
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:78 → 101
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:150 → 188
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:174 → 233
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75084819..75158595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533225.2 → XP_006533288.1  reticulon-4 receptor-like 1 isoform X1

      Conserved Domains (3) summary
      COG4886
      Location:108 → 308
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:131 → 154
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:227 → 286
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0S5.1 GenPept UniProtKB/Swiss-Prot:Q8K0S5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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