DUSP23 dual specificity phosphatase 23 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DUSP23provided by HGNC
Official Full Name: dual specificity phosphatase 23provided by HGNC
Primary source: HGNC:HGNC:21480
See related: Ensembl:ENSG00000158716 MIM:618361; AllianceGenome:HGNC:21480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: VHZ; LDP3; MOSP; LDP-3; DUSP25
Summary: Enables protein tyrosine/serine/threonine phosphatase activity. Involved in dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney (RPKM 18.6), liver (RPKM 13.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (159780962..159782543)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (158917974..158919555)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (159750752..159752333)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that DUSP23 mRNA levels in CD4+ T cells are higher in the systemic lupus erythematosus patients
Title: DUSP23 is over-expressed and linked to the expression of DNMTs in CD4(+) T cells from systemic lupus erythematosus patients.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
The upregulation of VHZ levels in primary human cancers supports the clinical relevance of this protein in cancers
Title: VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers.
Observational study of gene-disease association. (HuGE Navigator)
Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
DUSP23 showed distinctive phosphatase activity toward p-nitrophenyl phosphate, as well as oligopeptides containing phospho-tyrosine and phospho-threonine residues. Furthermore, DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in vitro
Title: Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain.
the smallest active protein-tyrosine phosphatase yet (only 16 kDa) belongs to the group of small Vaccinia virus VH1-related dual specific phosphatases; gene is located on human chromosome 1q23.1 and consists of only two coding exons
Title: The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: dual specificity protein phosphatase 23

Names: VH1-like member Z; VH1-like phosphatase Z; low-molecular-mass dual-specificity phosphatase 3; testicular tissue protein Li 59

NP_001306587.1

EC 3.1.3.16

EC 3.1.3.48

NP_001306588.1

EC 3.1.3.16

EC 3.1.3.48

NP_060293.2

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319658.2 → NP_001306587.1 dual specificity protein phosphatase 23

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AB164404, AL590560, BG823348, DA428735

Consensus CDS

CCDS1187.1

UniProtKB/Swiss-Prot

Q9BVJ7, Q9NX48

UniProtKB/TrEMBL

A0A140VJI5

Related

ENSP00000357087.1, ENST00000368107.2

Conserved Domains (1) summary

cd14504
Location:8 → 148

DUSP23; dual specificity phosphatase 23
NM_001319659.2 → NP_001306588.1 dual specificity protein phosphatase 23

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

BQ679163

Consensus CDS

CCDS1187.1

UniProtKB/Swiss-Prot

Q9BVJ7, Q9NX48

UniProtKB/TrEMBL

A0A140VJI5

Related

ENSP00000357089.1, ENST00000368109.5

Conserved Domains (1) summary

cd14504
Location:8 → 148

DUSP23; dual specificity phosphatase 23
NM_017823.5 → NP_060293.2 dual specificity protein phosphatase 23

See identical proteins and their annotated locations for NP_060293.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

BC001140, BQ679163

Consensus CDS

CCDS1187.1

UniProtKB/Swiss-Prot

Q9BVJ7, Q9NX48

UniProtKB/TrEMBL

A0A140VJI5

Related

ENSP00000357088.3, ENST00000368108.7

Conserved Domains (1) summary

cd14504
Location:8 → 148

DUSP23; dual specificity phosphatase 23