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    MINCR MYC-induced long non-coding RNA [ Homo sapiens (human) ]

    Gene ID: 100507316, updated on 10-Oct-2023

    Summary

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    Official Symbol
    MINCRprovided by HGNC
    Official Full Name
    MYC-induced long non-coding RNAprovided by HGNC
    Primary source
    HGNC:HGNC:51653
    See related
    Ensembl:ENSG00000253716 AllianceGenome:HGNC:51653
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC01604
    Expression
    Ubiquitous expression in fat (RPKM 4.1), thyroid (RPKM 2.9) and 25 other tissues See more
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    Genomic context

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    Location:
    8q24.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143280155..143281700, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144427547..144429093, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144362325..144363870, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144332854-144333354 Neighboring gene ZFP41 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144350631-144351453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144353055-144353555 Neighboring gene GLI family zinc finger 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144357207-144357850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144357851-144358494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144361711-144362353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144373076-144373651 Neighboring gene zinc finger protein 696 Neighboring gene uncharacterized LOC124902037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway. Bai S, et al. Acta Biochim Pol, 2022 Jun 29. PMID 35767742
    2. Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression. Li Z, et al. Neurochem Res, 2020 Jul. PMID 32333234
    3. Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer. Chen S, et al. Respir Res, 2019 Sep 3. PMID 31481083, Free PMC Article
    4. LncRNA MINCR activates Wnt/β-catenin signals to promote cell proliferation and migration in oral squamous cell carcinoma. Lyu Q, et al. Pathol Res Pract, 2019 May. PMID 30777615
    5. Overexpression of long non-coding RNA MINCR contributes to progressive clinicopathological features and poor prognosis of human hepatocellular carcinoma. Jin XL, et al. Eur Rev Med Pharmacol Sci, 2018 Dec. PMID 30556858

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A review on the role of MYC-induced long non-coding RNA in human disorders.
      Title: A review on the role of MYC-induced long non-coding RNA in human disorders.
    2. Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/beta-catenin signaling pathway.
      Title: Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway.
    3. Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression.
      Title: Long Non-coding RNA MINCR Regulates miR-876-5p/GSPT1 Axis to Aggravate Glioma Progression.
    4. Long non-coding RNA MINCR aggravates colon cancer via regulating miR-708-5p-mediated Wnt/beta-catenin pathway.
      Title: Long non-coding RNA MINCR aggravates colon cancer via regulating miR-708-5p-mediated Wnt/β-catenin pathway.
    5. LncRNA MINCR promotes the development of liver cancer by regulating microRNA-107/beta-catenin.
      Title: LncRNA MINCR promotes the development of liver cancer by regulating microRNA-107/β-catenin.
    6. Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma
      Title: Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma.
    7. MINCR exerted inhibitory effects on the cell cycle arrest and apoptosis of non-small cell lung cancer cells.
      Title: Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer.
    8. MINCR overexpression in hepatocellular carcinoma tissues correlates with clinicopathological disease progression and poor prognosis.
      Title: Overexpression of long non-coding RNA MINCR contributes to progressive clinicopathological features and poor prognosis of human hepatocellular carcinoma.
    9. Dysfunction of MINCR, miR-126 and SLC7A5 predicted poor prognosis of patients with non-small cell lung cancer.
      Title: Up-regulation of long noncoding RNA MINCR promotes non-small cell of lung cancer growth by negatively regulating miR-126/SLC7A5 axis.
    10. our findings revealed that MINCR may be an oncogene in oral squamous cell carcinoma via modulation of Wnt/beta-catenin pathway.
      Title: LncRNA MINCR activates Wnt/β-catenin signals to promote cell proliferation and migration in oral squamous cell carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • MYC-induced long noncoding RNA
    • TCONS_00015189
    • long intergenic non-protein coding RNA 1604

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_120682.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA992445, AC138696, AW975318, HY339014, HY368981
      Related
      ENST00000517411.4

    2. NR_120683.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' exon structure, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AA284855, AJ346444, BM987389, HY368981

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143280155..143281700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144427547..144429093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases