Ctsl cathepsin L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctslprovided by RGD
Official Full Name: cathepsin Lprovided by RGD
Primary source: RGD:2448
See related: Ensembl:ENSRNOG00000018566 AllianceGenome:RGD:2448
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CatL; CATHL; Ctsl1
Summary: Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 13282.8), Liver (RPKM 4121.4) and 6 other tissues See more
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Genomic context

Location:: 17p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (770104..776266)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (764370..770533)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (1873105..1879266, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cathepsin L induces apoptosis in rotenone-treated PC-12 cells via activation of B-Myb protein.
Title: Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins.
The results revealed that cathepsin B and L activity is required for maintenance of a fully differentiated state of thyrocytes featuring Taar1-bearing primary cilia.
Title: Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum.
In contrast to the weak levels of cathepsin L in normal glomeruli, on days 4 and 8, strong immunostaining was detected in almost all podocytes when proteinuria and pathological changes of the podocytes developed. Cathepsin L was reduced after day 28, but remained in a focal and segmental manner. Cystatin B, an intracellular inhibitor, was not detected in podocytes.
Title: Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis.
the activation of cathepsin L contributes to the irreversible depolarization produced by oxygen and glucose deprivation
Title: Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons.
Data indicate the role of a cathepsin-caspase 3 axis in the nuclear translocation of transcription Factor EB (TFEB) leading to lysosome biogenesis under conditions of sub-lethal oxidative stress.
Title: Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway.
Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
Title: Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
Inhibition of the activation of cathepsin L contributes to neuroprotection against cerebral ischemia.
Title: Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway.
Changes in olfaction were less consistent and widespread in the hippocampus, but were again sex specific for three genes: cathepsin-L (CtsL), matrix metalloproteinase-14 (MMP-14) and MMP-16.
Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide.
Title: The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide.
With aging, the level of cathepsin L delined at 18 month but rose at 24 month in brain.
Title: Alteration of cathepsins and actin genes expression in rat brain during ageing.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA923921 (e-PCR)
- UniSTS:239894

RH94583 (e-PCR)
- UniSTS:119831

Ctsl (e-PCR), detects polymorphism
- UniSTS:502679

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables kininogen binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables serpin family protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in CD4-positive, alpha-beta T cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in Sertoli cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of peptide antigen	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of peptide antigen	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagic cell death	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
involved_in elastin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in elastin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in enkephalin processing	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in fusion of virus membrane with host endosome membrane	ISO Inferred from Sequence Orthology more info
involved_in fusion of virus membrane with host plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis of virus by host cell	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to odorant	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in chromaffin granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: procathepsin L

Names: CP-2; MEP; cathepsin L1; cyclic protein 2; major excreted protein

NP_037288.1

EC 3.4.22.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013156.2 → NP_037288.1 procathepsin L preproprotein

See identical proteins and their annotated locations for NP_037288.1

Status: PROVISIONAL

Source sequence(s)

Y00697

UniProtKB/Swiss-Prot

P07154, Q9QV07

UniProtKB/TrEMBL

I2FHN3

Related

ENSRNOP00000025462.4, ENSRNOT00000025462.7

Conserved Domains (2) summary

smart00848
Location:29 → 87

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:114 → 332

Peptidase_C1; Papain family cysteine protease