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    CG5608 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41543, updated on 10-May-2024

    Summary

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    Official Symbol
    CG5608provided by FlyBase
    Primary source
    FLYBASE:FBgn0038058
    Locus tag
    Dmel_CG5608
    See related
    AllianceGenome:FB:FBgn0038058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5608; Vac14
    Summary
    Predicted to be involved in phosphatidylinositol biosynthetic process and positive regulation of kinase activity. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Predicted to be extrinsic component of vacuolar membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG5608 in Genome Data Viewer
    Location:
    87B11-87B12; 3-52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12462562..12465298, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8288284..8291020, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene toys are us Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit C Neighboring gene Heat shock protein 70 Ba Neighboring gene alphagamma-element:CR32865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FIG4 regulates lysosome membrane homeostasis independent of phosphatase function. Bharadwaj R, et al. Hum Mol Genet, 2016 Feb 15. PMID 26662798, Free PMC Article
    2. Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five? Bettencourt BR, et al. Mol Biol Evol, 2001 Jul. PMID 11420366
    3. Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila. Cernilogar FM, et al. Nature, 2011 Nov 6. PMID 22056986, Free PMC Article
    4. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article
    5. New levels of transcriptome complexity at upper thermal limits in wild Drosophila revealed by exon expression analysis. Telonis-Scott M, et al. Genetics, 2013 Nov. PMID 24002645, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PAS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5608-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12462562..12465298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141951.1 → NP_650208.1  uncharacterized protein Dmel_CG5608 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T989, Q9VG59
      Related
      FBpp0082148, FBtr0082680
      Conserved Domains (3) summary
      pfam11916
      Location:452 → 629
      Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
      pfam12755
      Location:65 → 161
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      sd00044
      Location:45 → 79
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T989 Q8T989
    Q9VG59 Q9VG59

    Gene LinkOut

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