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    MstProx [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40890, updated on 10-May-2024

    Summary

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    Official Symbol
    MstProxprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015770
    Locus tag
    Dmel_CG1149
    See related
    AllianceGenome:FB:FBgn0015770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1149; Dmel\CG1149; DmMstProx; dTLR3; dToll3; mstprox; Mstprox; Tl-3; toll; Toll-3; Toll3
    Summary
    Predicted to enable signaling receptor activity. Involved in signal transduction. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See MstProx in Genome Data Viewer
    Location:
    84D5-84D5; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7365939..7369305, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3191661..3195027, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Male-specific RNA 84Dc Neighboring gene Male-specific RNA 84Db Neighboring gene Male-specific RNA 84Da Neighboring gene long non-coding RNA:CR45560 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family. Mitcham JL, et al. J Biol Chem, 1996 Mar 8. PMID 8621445
    2. Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila. Levin TC, et al. Mol Biol Evol, 2017 Sep 1. PMID 28541576, Free PMC Article
    3. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Tauszig S, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973475, Free PMC Article
    4. Independent evolution of Toll and related genes in insects and mammals. Luo C, et al. Immunogenetics, 2000 Feb. PMID 10663571
    5. Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias. Lima LF, et al. BMC Genomics, 2021 Jul 21. PMID 34289811, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MstProx
    Names
    CG1149-PA
    MstProx-PA
    Toll-3
    NP_649719.2
    • point mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7365939..7369305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141462.2 → NP_649719.2  MstProx [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649719.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24164, Q9NBK6, Q9VIA4
      Conserved Domains (2) summary
      smart00255
      Location:823 → 960
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:325 → 345
      LRR_1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JP25 Q7JP25
    Q9NBK6 Q9NBK6
    Q9VIA4 Q9VIA4

    Gene LinkOut

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