SLC15A1 solute carrier family 15 member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC15A1provided by HGNC
Official Full Name: solute carrier family 15 member 1provided by HGNC
Primary source: HGNC:HGNC:10920
See related: Ensembl:ENSG00000088386 MIM:600544; AllianceGenome:HGNC:10920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PEPT1; HPECT1; HPEPT1
Summary: This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Expression: Biased expression in small intestine (RPKM 105.5), duodenum (RPKM 76.1) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q32.2-q32.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (98683801..98752672, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (97893752..97962601, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (99336055..99404926, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors.
Title: Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors.
Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1.
Title: Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1.
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target.
Title: PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target.
Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity.
Title: Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity.
Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization.
Title: Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization.
Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.
Title: Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.
SLC15A1 rs2297322 and rs1289389 polymorphisms were associated with alterations in the risk of dyslipidaemia.
Title: Association of SLC15A1 polymorphisms with susceptibility to dyslipidaemia in a Chinese Han population.
PepT1 could serve as a desirable target for oral nanoparticulate drug delivery.
Title: Dipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy.
REVIEW: summarizes the progress made in the regulation of PepT1 and provides insights into the PepT1's potential in clinical aspects of nutritional and drug therapies
Title: Regulation profile of the intestinal peptide transporter 1 (PepT1).
Although small intestinal PEPT1 expression tended to be lower in neonates than in older children, this difference is small and tissue distribution is similar. This finding suggests similar oral absorption of PEPT1 substrates across the pediatric age range.
Title: Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13S1019 (e-PCR)
- UniSTS:152352

D8S2279 (e-PCR)
- UniSTS:473907

PMC140024P1 (e-PCR)
- UniSTS:270905

PMC140024P10 (e-PCR)
- UniSTS:270906

PMC140024P11 (e-PCR)
- UniSTS:270907

PMC140024P12 (e-PCR)
- UniSTS:270908

PMC140024P13 (e-PCR)
- UniSTS:270909

PMC140024P14 (e-PCR)
- UniSTS:270910

PMC140024P15 (e-PCR)
- UniSTS:270911

PMC140024P16 (e-PCR)
- UniSTS:270912

PMC140024P2 (e-PCR)
- UniSTS:270916

PMC140024P3 (e-PCR)
- UniSTS:270921

PMC140024P4 (e-PCR)
- UniSTS:270922

PMC140024P5 (e-PCR)
- UniSTS:270923

PMC140024P6 (e-PCR)
- UniSTS:270924

PMC140024P7 (e-PCR)
- UniSTS:270925

PMC140024P8 (e-PCR)
- UniSTS:270926

PMC140024P9 (e-PCR)
- UniSTS:270927

L18426 (e-PCR)
- UniSTS:34648

RH70582 (e-PCR)
- UniSTS:9052

SLC15A1_722 (e-PCR)
- UniSTS:277718

SHGC-147222 (e-PCR)
- UniSTS:172773

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide:proton symporter activity	TAS Traceable Author Statement more info
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables tripeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables tripeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transport	TAS Traceable Author Statement more info
involved_in peptide transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tripeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 15 member 1

Names: Caco-2 oligopeptide transporter; intestinal H+/peptide cotransporter; macrophage oligopeptide transporter PEPT1; peptide transporter 1; solute carrier family 15 (oligopeptide transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.