TCEAL7 transcription elongation factor A like 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TCEAL7provided by HGNC
Official Full Name: transcription elongation factor A like 7provided by HGNC
Primary source: HGNC:HGNC:28336
See related: Ensembl:ENSG00000182916 MIM:300771; AllianceGenome:HGNC:28336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WEX5
Summary: Predicted to enable WW domain binding activity. Involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 45.0), endometrium (RPKM 18.0) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq22.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (103330239..103332326)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (101777239..101779326)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (102585167..102587254)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p.
Title: Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p.
These results suggest that miR-301a promotes radiation resistance by repressing anti-oncogene TCEAL7 expression and then activity of the Wnt/beta-catenin-signaling pathway.
Title: Hypoxic Glioma Cell-Secreted Exosomal miR-301a Activates Wnt/β-catenin Signaling and Promotes Radiation Resistance by Targeting TCEAL7.
Findings show that TCEAL7 expression is down-regulated in non-small cell lung cancer (NSCLC) like in other human cancers. This down-regulation was also associated with CCND1 over-expression in lung tumors.
Title: Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.
Our study suggests that TCEAL7 might serve as a candidate tumor suppressor and a potential prognostic biomarker in gastric carcinogenesis.
Title: Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis.
alteration of TCEAL7 expression levels in recombination-based alternative lengthening of telomeres and telomerase-positive cells affects hTERT expression
Title: TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.
TCEAL7 in the negative regulation of NF-kappaB signaling at the basal level by modulating transcriptional activity of NF-kappaB on its target gene promoters in ovarian cells.
Title: TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway.
TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers.
Title: Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation is reported.
Title: A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation.
TCEAL7 is a cell death regulatory protein that is frequently inactivated in ovarian cancers, and may function as a tumor suppressor.
Title: Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription elongation factor A protein-like 7

Names: TCEA-like protein 7; transcription elongation factor A (SII)-like 7; transcription elongation factor S-II protein-like 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348258.2 → NP_001335187.1 transcription elongation factor A protein-like 7

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AI753521, BC016786, BQ878422

Consensus CDS

CCDS14506.1

UniProtKB/Swiss-Prot

B3KSV2, Q96AT4, Q9BRU2

Related

ENSP00000361751.1, ENST00000372666.1

Conserved Domains (1) summary

pfam04538
Location:1 → 100

BEX; Brain expressed X-linked like family
NM_152278.5 → NP_689491.1 transcription elongation factor A protein-like 7

See identical proteins and their annotated locations for NP_689491.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AI753521, BC016786, DA142141, DB481725

Consensus CDS

CCDS14506.1

UniProtKB/Swiss-Prot

B3KSV2, Q96AT4, Q9BRU2

Related

ENSP00000329794.4, ENST00000332431.5

Conserved Domains (1) summary

pfam04538
Location:1 → 100

BEX; Brain expressed X-linked like family