cdc-73 Cell division cycle protein 73 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cdc-73
Gene description: Cell division cycle protein 73
Primary source: WormBase:WBGene00018064
Locus tag: CELE_F35F11.1
See related: AllianceGenome:WB:WBGene00018064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in positive regulation of transcription elongation from RNA polymerase II promoter and recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex. Predicted to be located in nucleus. Predicted to be part of Cdc73/Paf1 complex. Is expressed in body wall musculature; nervous system; non-striated muscle; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (4042575..4047572)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35F11.e (e-PCR)
- UniSTS:324230

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cdc73/Paf1 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cell division cycle protein 73

NP_500465.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

4042575..4047572

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068064.8 → NP_500465.4 Cell division cycle protein 73 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500465.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N5U5

Conserved Domains (2) summary

pfam05179
Location:351 → 502

CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal

pfam16050
Location:28 → 279

CDC73_N; Paf1 complex subunit CDC73 N-terminal