aco-1 Cytoplasmic aconitate hydratase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: aco-1
Gene description: Cytoplasmic aconitate hydratase
Primary source: WormBase:WBGene00000040
Locus tag: CELE_ZK455.1
See related: AllianceGenome:WB:WBGene00000040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables aconitate hydratase activity. Involved in tricarboxylic acid metabolic process. Located in cytosol. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including ACO1 (aconitase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See aco-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (11339874..11343327)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

biochemical characterization and regulation
Title: Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK455.1 (e-PCR)
- UniSTS:308272

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
NOT enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aconitate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in citrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cytoplasmic aconitate hydratase

NP_509898.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11339874..11343327

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077497.4 → NP_509898.1 Cytoplasmic aconitate hydratase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509898.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23500

Conserved Domains (3) summary

cd01586
Location:80 → 565

AcnA_IRP; Aconitase A catalytic domain

cd01580
Location:668 → 835

AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...

PTZ00092
Location:3 → 887

PTZ00092; aconitate hydratase-like protein; Provisional