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    phf-10 PHD finger protein 10;PHD-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565141, updated on 12-Jun-2024

    Summary

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    Gene symbol
    phf-10
    Gene description
    PHD finger protein 10;PHD-type domain-containing protein
    Locus tag
    CELE_F33E11.6
    See related
    AllianceGenome:WB:WBGene00018013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone acetyltransferase activity (H4-K16 specific); histone binding activity; and transcription coregulator activity. Predicted to be involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MSL complex. Used to study alcohol use disorder. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See phf-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (304810..311565, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 'chromo' domain containing protein;Mediator complex subunit 6 Neighboring gene Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene ABC transporter domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans. Mathies LD, et al. Proc Natl Acad Sci U S A, 2015 Mar 10. PMID 25713357, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 10;PHD-type domain-containing protein
    NP_001041112.1
    • Partially confirmed by transcript evidence
    NP_001041113.1
    • Confirmed by transcript evidence
    NP_001300097.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      304810..311565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047648.4 → NP_001041113.1  PHD finger protein 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2A950
      Conserved Domains (2) summary
      cd15528
      Location:334 → 380
      PHD1_PHF10; PHD finger 1 found in PHD finger protein 10 (PHF10) and similar proteins
      cd15529
      Location:382 → 424
      PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

    2. NM_001313168.3 → NP_001300097.1  PHD-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AS00
      Conserved Domains (1) summary
      cl22851
      Location:38 → 80
      PHD_SF; PHD finger superfamily

    3. NM_001047647.6 → NP_001041112.1  PHD finger protein 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2A949
    Nucleotide Protein
    Heading Accession and Version

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