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    unc-26 Synaptojanin [ Caenorhabditis elegans ]

    Gene ID: 178284, updated on 12-Jun-2024

    Summary

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    Gene symbol
    unc-26
    Gene description
    Synaptojanin
    Locus tag
    CELE_JC8.10
    See related
    AllianceGenome:WB:WBGene00006763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including positive regulation of necrotic cell death; vesicle organization; and vesicle uncoating. Located in synapse. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to several human genes including SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See unc-26 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (13261555..13272516, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein Neighboring gene Cleavage and polyadenylation specificity factor subunit 3 Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism. Dong Y, et al. Elife, 2015 Apr 28. PMID 25918845, Free PMC Article
    2. Mutations in synaptojanin disrupt synaptic vesicle recycling. Harris TW, et al. J Cell Biol, 2000 Aug 7. PMID 10931870, Free PMC Article
    3. Genetic and fine structure analysis of unc-26(IV) and adjacent regions in Caenorhabditis elegans. Charest DL, et al. Mol Gen Genet, 1990 May. PMID 2381425
    4. Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Schuske KR, et al. Neuron, 2003 Nov 13. PMID 14622579
    5. Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. Rangaraju S, et al. Elife, 2015 Dec 1. PMID 26623667, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle uncoating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acetylcholine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of backward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of forward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle uncoating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Synaptojanin
    NP_001023265.1
    • Confirmed by transcript evidence
    NP_001023266.1
    • Confirmed by transcript evidence
    NP_001122785.1
    • Confirmed by transcript evidence
    NP_001129862.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13261555..13272516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028094.5 → NP_001023265.1  Synaptojanin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECL2
      Conserved Domains (3) summary
      cd09089
      Location:521 → 829
      INPP5c_Synj; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanins
      pfam02383
      Location:60 → 336
      Syja_N; SacI homology domain
      cl17169
      Location:844 → 972
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001028095.6 → NP_001023266.1  Synaptojanin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023266.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3CJ53, G5ECL2, G5EDR8, G5EEJ9
      Conserved Domains (3) summary
      cd09089
      Location:527 → 835
      INPP5c_Synj; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanins
      pfam02383
      Location:60 → 336
      Syja_N; SacI homology domain
      cl17169
      Location:850 → 978
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001136390.4 → NP_001129862.1  Synaptojanin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129862.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECL2
      Conserved Domains (1) summary
      pfam02383
      Location:60 → 336
      Syja_N; SacI homology domain

    4. NM_001129313.3 → NP_001122785.1  Synaptojanin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122785.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECL2
      Conserved Domains (1) summary
      pfam02383
      Location:60 → 336
      Syja_N; SacI homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECL2.1

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