mex-5 Zinc finger protein mex-5 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: mex-5
Gene description: Zinc finger protein mex-5
Locus tag: CELE_W02A2.7
See related: AllianceGenome:WB:WBGene00003230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule and centrosome. Is expressed in germ line; head muscle; head neurons; intestine; and somatic nervous system. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mex-5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (13353723..13356104)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5.
Title: A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5.
The polo-like kinase PLK-1 mediates the repulsive coupling between MEX-5 and POS-1 by increasing the mobility of POS-1 in the anterior.
Title: Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.
Antagonistic activities of PAR-1 and PP2A regulate MEX-5 diffusion to establish the MEX-5 protein gradient along the anterior-to-posterior axis of the one-cell C. elegans embryo.
Title: Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle.
asymmetric cortically localized PAR proteins mediate the anterior enrichment of MEX-5 by reversibly changing its diffusion rate at spatially distinct points in the embryo
Title: MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion.
vivo. PAR-1 and PAR-4 kinase activities are required for the phosphorylation of S458, providing a link between PAR polarity proteins and the cytoplasmic asymmetry of MEX-5
Title: MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.
Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX-6.
Title: Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.
analysis of RNA recognition by the embryonic polarity determinant MEX-5
Title: Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.
Degradation of this maternally supplied cell fate determinant is delayed in oma-1 (zu405) mutant embryos.
Title: A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02A2.7 (e-PCR)
- UniSTS:317613

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly-pyrimidine tract binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zinc finger protein mex-5

NP_502566.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13353723..13356104

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070165.7 → NP_502566.1 Zinc finger protein mex-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502566.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XUB2

Conserved Domains (2) summary

smart00356
Location:270 → 298

ZnF_C3H1; zinc finger

pfam00642
Location:315 → 342

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)