C5ar1 complement C5a receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C5ar1provided by RGD
Official Full Name: complement C5a receptor 1provided by RGD
Primary source: RGD:70553
See related: AllianceGenome:RGD:70553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C5aR; C5r1; C5a-R
Summary: Enables complement component C5a binding activity and complement component C5a receptor activity. Involved in several processes, including animal organ regeneration; negative regulation of neuron apoptotic process; and response to lipopolysaccharide. Located in cell surface and plasma membrane. Used to study adult respiratory distress syndrome; amyotrophic lateral sclerosis; neutropenia; obesity; and thrombosis. Biomarker of asthma and lung disease. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 44.4), Spleen (RPKM 33.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86077309..86088001, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (76948622..76959826, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78186777..78195132, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Title: C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap.
Title: Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap.
C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion.
Title: C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion.
Study concludes, Toll-like receptor 4 (TLR4) and C5aR1 played a vital role during ischemia and reperfusion brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways.
Title: Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways.
The C5aR expression was upregulated and localized to neurons and microglia in spinal cord ischemia reperfusion injury in the rat.
Title: Expression of C5a and its receptor following spinal cord ischemia reperfusion injury in the rat.
C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations
Title: Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
C5aR is critically involved in ventricular remodeling by regulating inflammatory responses in the hypertensive heart.
Title: Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats.
present in bone forming osteoblasts and bone resorbing osteoclasts, suggesting role in fracture healing
Title: The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro.
These results demonstrate that CD88 is expressed on presynaptic terminals of mossy fibres within the CA3 region of the hippocampus.
Title: The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres.
C5a receptors and C5L2 were demonstrated in the rat anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH.
Title: Complement C5a receptors in the pituitary gland: expression and function.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C5a binding	IDA Inferred from Direct Assay more info	PubMed
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C5a receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables complement component C5a receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C5a receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in hindbrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in complement component C5a signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in presynapse organization	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to peptidoglycan	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C5a anaphylatoxin chemotactic receptor 1

Names: complement component 5, receptor 1; complement component 5a receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053619.2 → NP_446071.1 C5a anaphylatoxin chemotactic receptor 1

See identical proteins and their annotated locations for NP_446071.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O09088, P97520

UniProtKB/TrEMBL

A6J8A2

Conserved Domains (1) summary

pfam00001
Location:55 → 302

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

86077309..86088001 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105863.2 → XP_038961791.1 C5a anaphylatoxin chemotactic receptor 1 isoform X1

Conserved Domains (2) summary

cd14964
Location:17 → 43

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:16 → 290

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily