Srd5a1 steroid 5 alpha-reductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srd5a1provided by RGD
Official Full Name: steroid 5 alpha-reductase 1provided by RGD
Primary source: RGD:3757
See related: Ensembl:ENSRNOG00000017601 AllianceGenome:RGD:3757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S5AR 1
Summary: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including animal organ development; cellular hormone metabolic process; and cellular response to organic cyclic compound. Located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 679.7) and Adrenal (RPKM 58.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (35514914..35548898)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (33686069..33720468)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (36320504..36354694)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ziram inhibited SRD5A1 and AKR1C14 activities, thus possibly interfering with neurosteroid production in rats.
Title: Ziram inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase.
Exposure of middle-aged rats to environmental enrichment increased mRNA levels of 5al;pha-reductase-1, 3alpha-HSD and cytochrome P450 17alpha-hydroxylase/c17,20-lyase and decreased the methylation state of the 5alpha-reductase-1 gene
Title: Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5α-reductase type 1 gene in the rat hippocampus.
The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin resistance in male rats and mice are reported.
Title: 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents.
Low Srd5a1 expression is associated with benign prostatic hypertrophy.
Title: Bisphenol A exposure during adulthood alters expression of aromatase and 5α-reductase isozymes in rat prostate.
Changes in the expression of steroid 5-alpha reductase isoenzymes in the prostate in response to environmental stress.
Title: Expression of steroid 5α-reductase isozymes in prostate of adult rats after environmental stress.
Tesosterone concentrations during postnatal sexual differentiation of the rat central nervous system, among other sex-dependent factors, influence brain levels of 5alpha-Reductase isozymes in adulthood
Title: Steroid 5α-reductase in adult rat brain after neonatal testosterone administration.
Elevated levels of 5alpha-reduced androgens seen in hyperinsulinemic conditions might be explained on the basis of a stimulatory effect of insulin on 5alpha-reductase in granulosa cells.
Title: Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells.
Thus, the present results indicate that the vitamin E-induced regulation of SRD5A1 and GCLM in rat liver is not directly mediated by changes in promoter DNA methylation.
Title: Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver.
Data suggest that Sp1 and Sp3 play a role in the regulation of 5alpha-R gene expression, and hence the production of 5alpha-reduced neurosteroids in glial cells.
Title: Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors.
Our results suggest that 5AR inhibitors elicit antipsychotic-like effects in animals and may be proposed as a putative novel target in the management of psychotic disorders.
Title: Antipsychotic-like properties of 5-alpha-reductase inhibitors.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH140207 (e-PCR)
- UniSTS:222286

Srd5a1 (e-PCR), detects polymorphism
- UniSTS:144507

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables NADPH binding	IDA Inferred from Direct Assay more info	PubMed
enables amide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in androgen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in androgen catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in androgen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bone development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epinephrine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in diterpenoid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in female genitalia development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male genitalia development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in progesterone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to follicle-stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in urogenital system development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Names: SR type 1; steroid 5-alpha-reductase; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

NP_058766.2

EC 1.3.1.22

XP_038957088.1

EC 1.3.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017070.3 → NP_058766.2 3-oxo-5-alpha-steroid 4-dehydrogenase 1

See identical proteins and their annotated locations for NP_058766.2

Status: VALIDATED

Source sequence(s)

BC088303, CO394005, CV112588, J05035

UniProtKB/Swiss-Prot

A0JPJ6, P24008

UniProtKB/TrEMBL

A6JV19

Related

ENSRNOP00000023659.6, ENSRNOT00000023659.7

Conserved Domains (1) summary

pfam02544
Location:106 → 255

Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

35514914..35548898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101160.2 → XP_038957088.1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1

Conserved Domains (1) summary

cl21511
Location:106 → 185

PEMT; Phospholipid methyltransferase