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    Coro2a coronin 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313235, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Coro2aprovided by RGD
    Official Full Name
    coronin 2Aprovided by RGD
    Primary source
    RGD:1309719
    See related
    Ensembl:ENSRNOG00000008901 AllianceGenome:RGD:1309719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be located in brush border. Predicted to be part of transcription repressor complex. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 42.1), Brain (RPKM 33.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65623820..65677483, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60825630..60881917, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (62154526..62210797, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate synthase Neighboring gene tripartite motif-containing 14 Neighboring gene uncharacterized LOC108350963 Neighboring gene uncharacterized LOC108350962 Neighboring gene TBC1 domain family, member 2 Neighboring gene uncharacterized LOC120102869

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. Marshall TW, et al. J Cell Sci, 2009 Sep 1. PMID 19654210, Free PMC Article
    2. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. Yoon HG, et al. EMBO J, 2003 Mar 17. PMID 12628926, Free PMC Article
    3. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
    4. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coronin 2A and cofilin regulate a subset of focal-adhesion-turnover events.
      Title: Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coronin-2A
    Names
    coronin, actin binding protein 2A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012101.2 → NP_001012101.2  coronin-2A

      Status: VALIDATED

      Source sequence(s)
      BC079209, JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2QC56, A6IJC5
      Related
      ENSRNOP00000011787.7, ENSRNOT00000011787.8
      Conserved Domains (6) summary
      PTZ00421
      Location:29 → 536
      PTZ00421; coronin; Provisional
      pfam08953
      Location:27 → 84
      DUF1899; Domain of unknown function (DUF1899)
      pfam13863
      Location:496 → 534
      DUF4200; Domain of unknown function (DUF4200)
      pfam16300
      Location:369 → 411
      WD40_4; Type of WD40 repeat
      sd00039
      Location:59 → 99
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:98 → 327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      65623820..65677483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238058.5 → XP_006238120.1  coronin-2A isoform X2

      See identical proteins and their annotated locations for XP_006238120.1

      UniProtKB/TrEMBL
      A6IJC5, F1LSP7, Q6AY36
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_063287629.1 → XP_063143699.1  coronin-2A isoform X2

      UniProtKB/TrEMBL
      F1LSP7, Q6AY36

    3. XM_017593364.3 → XP_017448853.1  coronin-2A isoform X1

      UniProtKB/TrEMBL
      A0A0G2QC56, A6IJC5
      Conserved Domains (6) summary
      PTZ00421
      Location:29 → 536
      PTZ00421; coronin; Provisional
      pfam08953
      Location:27 → 84
      DUF1899; Domain of unknown function (DUF1899)
      pfam13863
      Location:496 → 534
      DUF4200; Domain of unknown function (DUF4200)
      pfam16300
      Location:369 → 411
      WD40_4; Type of WD40 repeat
      sd00039
      Location:59 → 99
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:98 → 327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_039109864.2 → XP_038965792.1  coronin-2A isoform X2

      UniProtKB/TrEMBL
      A6IJC5, F1LSP7, Q6AY36
      Conserved Domains (2) summary
      sd00039
      Location:40 → 80
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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