Dcdc2 doublecortin domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcdc2provided by RGD
Official Full Name: doublecortin domain containing 2provided by RGD
Primary source: RGD:1310227
See related: Ensembl:ENSRNOG00000017511 AllianceGenome:RGD:1310227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Knockdown of this gene expression results in neuronal migration disorders similar to those seen in the brains of dyslexics. [provided by RefSeq, Sep 2010]
Expression: Biased expression in Kidney (RPKM 69.6), Uterus (RPKM 22.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (40274009..40459757, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (39845952..40031781, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (41838201..42031265, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia
Title: Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons.
These results support the claim that knockdown of Dcdc2 expression results in neuronal migration disorders similar to those seen in the brains of dyslexics.
Title: Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of visual learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinocilium	IBA Inferred from Biological aspect of Ancestor more info
located_in kinocilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: doublecortin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106110.2 → NP_001099580.2 doublecortin domain-containing protein 2

See identical proteins and their annotated locations for NP_001099580.2

Status: REVIEWED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

D3ZR10

UniProtKB/TrEMBL

A0A8I5YBZ0

Related

ENSRNOP00000060289.1, ENSRNOT00000068021.2

Conserved Domains (3) summary

TIGR00927
Location:250 → 445

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

40274009..40459757 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095510.2 → XP_038951438.1 doublecortin domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

D3ZR10

UniProtKB/TrEMBL

A0A8I5YBZ0

Conserved Domains (3) summary

TIGR00927
Location:250 → 445

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039095509.2 → XP_038951437.1 doublecortin domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

D3ZR10

UniProtKB/TrEMBL

A0A8I5YBZ0

Conserved Domains (3) summary

TIGR00927
Location:250 → 445

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039095511.2 → XP_038951439.1 doublecortin domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A6KLE2

Conserved Domains (2) summary

COG5271
Location:96 → 276

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cl28922
Location:1 → 46

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold