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    Slc22a21 solute carrier family 22 (organic cation transporter), member 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303140, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Slc22a21provided by RGD
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 21provided by RGD
    Primary source
    RGD:1561735
    See related
    Ensembl:ENSRNOG00000069239 AllianceGenome:RGD:1561735
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Octn3
    Expression
    Biased expression in Kidney (RPKM 127.6), Testes (RPKM 101.0) and 9 other tissues See more
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    Genomic context

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    See Slc22a21 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38605665..38633376, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38104114..38133106, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39296904..39324861, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480792 Neighboring gene cyclin-dependent kinase 4, pseudogene 2 Neighboring gene solute carrier family 22 member 4 Neighboring gene PDZ and LIM domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: anatomical evidence for a stress hormone-sensitive dopamine clearance system. Hill JE, et al. J Chem Neuroanat, 2013 Sep. PMID 23694905
    2. Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist. Januszewicz E, et al. Int J Biochem Cell Biol, 2009 Dec. PMID 19735737
    3. Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Nagai K, et al. Arch Biochem Biophys, 2006 Aug 1. PMID 16839516
    4. OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane. Durán JM, et al. J Cell Physiol, 2005 Mar. PMID 15389639

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OCTN3 is densely expressed within the intercalated cell groups of the amygdala.
      Title: Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: anatomical evidence for a stress hormone-sensitive dopamine clearance system.
    2. a physiological role of OCTN3 as peroxisomal membrane transporter.
      Title: Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.
    3. Results demonstrate that mammalian small intestine expresses OCTN3 mRNA along the villus and that OCTN3 protein is located in the basolateral membrane.
      Title: OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carnitine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carnitine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cartregulin; organic cation/carnitine transporter 2; solute carrier family 22 member 21
    Names
    solute carrier family 22 member 5
    up-regulator of carnitine transporter, OCTN2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38605665..38633376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087194.2 → XP_038943122.1  solute carrier family 22 member 21 isoform X2

      Conserved Domains (1) summary
      TIGR00898
      Location:52 → 357
      2A0119; cation transport protein

    2. XM_008767743.4 → XP_008765965.1  solute carrier family 22 member 21 isoform X1

      See identical proteins and their annotated locations for XP_008765965.1

      UniProtKB/TrEMBL
      A0A8I6GM55, A6HEF6, A6HEF7
      Related
      ENSRNOP00000096599.1
      Conserved Domains (2) summary
      cd06174
      Location:123 → 513
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12 → 523
      2A0119; cation transport protein

    3. XM_039087195.2 → XP_038943123.1  solute carrier family 22 member 21 isoform X3

      Conserved Domains (1) summary
      TIGR00898
      Location:1 → 347
      2A0119; cation transport protein

    4. XM_039087198.2 → XP_038943126.1  organic cation/carnitine transporter 2 isoform X6

      Conserved Domains (1) summary
      TIGR00898
      Location:12 → 317
      2A0119; cation transport protein

    5. XM_039087196.2 → XP_038943124.1  solute carrier family 22 member 21 isoform X4

      Conserved Domains (1) summary
      TIGR00898
      Location:12 → 353
      2A0119; cation transport protein

    6. XM_039087197.2 → XP_038943125.1  organic cation/carnitine transporter 2 isoform X5

      Conserved Domains (1) summary
      TIGR00898
      Location:12 → 322
      2A0119; cation transport protein
    Nucleotide Protein Strain
    Heading Accession and Version

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