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    muc5.2 mucin 5.2 [ Danio rerio (zebrafish) ]

    Gene ID: 572172, updated on 27-Mar-2024

    Summary

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    Official Symbol
    muc5.2provided by ZNC
    Official Full Name
    mucin 5.2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121108-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-121108-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    muc5b
    Summary
    Predicted to enable hormone activity. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in pharynx. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See muc5.2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8407892..8431535)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8330824..8368281)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene intestinal mucin-like protein Neighboring gene intestinal mucin-like protein Neighboring gene mucin 5.1, oligomeric mucus/gel-forming Neighboring gene mucin-2-like Neighboring gene FA complementation group I Neighboring gene polymerase (DNA directed), gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Lang T, et al. Mol Biol Evol, 2016 Aug. PMID 27189557, Free PMC Article
    2. Zebrafish as a model to study live mucus physiology. Jevtov I, et al. Sci Rep, 2014 Oct 17. PMID 25323747, Free PMC Article
    3. Effects of the Essential Oil from Pistacia lentiscus Var. chia on the Lateral Line System and the Gene Expression Profile of Zebrafish (Danio rerio). Serifi I, et al. Molecules, 2019 Oct 30. PMID 31671694, Free PMC Article
    4. Deficiency in macrophage-stimulating protein results in spontaneous intestinal inflammation and increased susceptibility toward epithelial damage in zebrafish. Witte M, et al. Zebrafish, 2014 Dec. PMID 25353089
    5. Gel-forming mucins appeared early in metazoan evolution. Lang T, et al. Proc Natl Acad Sci U S A, 2007 Oct 9. PMID 17911254, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mucin 5.2; mucin-2
    Names
    mucin 5b
    unm_sa927

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      8407892..8431535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470778.1 → XP_021326453.1  mucin-2

      UniProtKB/TrEMBL
      A0A8M9PHK0
      Conserved Domains (7) summary
      smart00215
      Location:841 → 892
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:868 → 1027
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1065 → 1137
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:416 → 564
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:320 → 376
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:249 → 316
      C8; C8 domain
      cl26464
      Location:1269 → 1639
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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