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    Lrrtm3 leucine rich repeat transmembrane neuronal 3 [ Mus musculus (house mouse) ]

    Gene ID: 216028, updated on 8-May-2024

    Summary

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    Official Symbol
    Lrrtm3provided by MGI
    Official Full Name
    leucine rich repeat transmembrane neuronal 3provided by MGI
    Primary source
    MGI:MGI:2389177
    See related
    Ensembl:ENSMUSG00000042846 AllianceGenome:MGI:2389177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630044H04Rik
    Summary
    Acts upstream of or within positive regulation of amyloid-beta formation and positive regulation of synapse assembly. Located in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; future brain; and male reproductive gland or organ. Orthologous to human LRRTM3 (leucine rich repeat transmembrane neuronal 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 10.4), cortex adult (RPKM 6.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 32.57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63764276..63926034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63928497..64090255, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1121 Neighboring gene STARR-positive B cell enhancer ABC_E2940 Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene catenin alpha 3 Neighboring gene STARR-seq mESC enhancer starr_26935 Neighboring gene STARR-seq mESC enhancer starr_26936 Neighboring gene predicted gene, 30644 Neighboring gene STARR-seq mESC enhancer starr_26937 Neighboring gene STARR-seq mESC enhancer starr_26939 Neighboring gene STARR-seq mESC enhancer starr_26940 Neighboring gene STARR-seq mESC enhancer starr_26941 Neighboring gene STARR-seq mESC enhancer starr_26942 Neighboring gene STARR-seq mESC enhancer starr_26944 Neighboring gene STARR-seq mESC enhancer starr_26945 Neighboring gene STARR-seq mESC enhancer starr_26947 Neighboring gene STARR-seq mESC enhancer starr_26948 Neighboring gene STARR-seq mESC enhancer starr_26949 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits. Kim J, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35022233, Free PMC Article
    2. LRRTM3 is dispensable for amyloid-β production in mice. Laakso T, et al. J Alzheimers Dis, 2012. PMID 22710909
    3. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Majercak J, et al. Proc Natl Acad Sci U S A, 2006 Nov 21. PMID 17098871, Free PMC Article
    4. LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding. Um JW, et al. Cell Rep, 2016 Feb 2. PMID 26776509
    5. Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Haines BP, et al. Gene Expr Patterns, 2007 Jan. PMID 16860615

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits.
      Title: LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits.
    2. LRRTM3 is required for dentate gyrus excitatory synapse development and regulates activity-dependent AMPAR surface expression.
      Title: LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.
    3. protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD
      Title: LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of amyloid-beta formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat transmembrane neuronal protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178678.4 → NP_848793.1  leucine-rich repeat transmembrane neuronal protein 3 precursor

      See identical proteins and their annotated locations for NP_848793.1

      Status: PROVISIONAL

      Source sequence(s)
      AC116138, AC158604
      Consensus CDS
      CCDS35925.1
      UniProtKB/Swiss-Prot
      Q14CH3, Q3TQA3, Q8BGJ7, Q8BZ81
      UniProtKB/TrEMBL
      Q8BZA0
      Related
      ENSMUSP00000101079.2, ENSMUST00000105439.2
      Conserved Domains (4) summary
      smart00013
      Location:33 → 61
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:81 → 300
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:66 → 86
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:133 → 193
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63764276..63926034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZ81.2 GenPept UniProtKB/Swiss-Prot:Q8BZ81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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