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    TCF7L2 transcription factor 7 like 2 [ Neogale vison (American mink) ]

    Gene ID: 122901120, updated on 22-Mar-2024

    Summary

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    Gene symbol
    TCF7L2
    Gene description
    transcription factor 7 like 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Neogale vison
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Neogale
    Also known as
    Tcf-4; F8W742
    Orthologs
    human mouse all
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    Genomic context

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    See TCF7L2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    100 current ASM_NN_V1 (GCF_020171115.1) 2 NC_058092.1 (223205567..223403365)

    Chromosome 2 - NC_058092.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene hyaluronan binding protein 2 Neighboring gene nebulin related anchoring protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_058092.1 Chromosome 2 Reference ASM_NN_V1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TGF-beta induces novel Lef-1 splice variants through a Smad-independent signaling pathway. Cordray P, et al. Dev Dyn, 2005 Apr. PMID 15736165

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin-TCF7L2 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 7-like 2
    Names
    T-cell transcription factor 4
    Transcription factor 7-like 2 (T-cell-specific, HMG-box)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Neovison vison Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM_NN_V1 Primary Assembly

    Genomic

    1. NC_058092.1 Reference ASM_NN_V1 Primary Assembly

      Range
      223205567..223403365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_044240523.1 → XP_044096458.1  transcription factor 7-like 2 isoform X1

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    2. XM_044240528.1 → XP_044096463.1  transcription factor 7-like 2 isoform X6

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    3. XM_044240527.1 → XP_044096462.1  transcription factor 7-like 2 isoform X5

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    4. XM_044240526.1 → XP_044096461.1  transcription factor 7-like 2 isoform X4

      Conserved Domains (2) summary
      cd01388
      Location:401 → 468
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    5. XM_044240525.1 → XP_044096460.1  transcription factor 7-like 2 isoform X3

      Conserved Domains (2) summary
      cd01388
      Location:402 → 469
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    6. XM_044240524.1 → XP_044096459.1  transcription factor 7-like 2 isoform X2

      Conserved Domains (2) summary
      cd01388
      Location:405 → 472
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 306
      CTNNB1_binding; N-terminal CTNNB1 binding

    7. XM_044240529.1 → XP_044096464.1  transcription factor 7-like 2 isoform X7

      Conserved Domains (2) summary
      cd01388
      Location:383 → 450
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 284
      CTNNB1_binding; N-terminal CTNNB1 binding

    8. XM_044240530.1 → XP_044096465.1  transcription factor 7-like 2 isoform X8

      UniProtKB/TrEMBL
      A0A8C7AIG3
      Conserved Domains (1) summary
      cd01388
      Location:374 → 441
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

    9. XM_044240548.1 → XP_044096483.1  transcription factor 7-like 2 isoform X24

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    10. XM_044240549.1 → XP_044096484.1  transcription factor 7-like 2 isoform X25

      Conserved Domains (2) summary
      cd01388
      Location:405 → 472
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 306
      CTNNB1_binding; N-terminal CTNNB1 binding

    11. XM_044240544.1 → XP_044096479.1  transcription factor 7-like 2 isoform X21

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    12. XM_044240550.1 → XP_044096485.1  transcription factor 7-like 2 isoform X26

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    13. XM_044240532.1 → XP_044096467.1  transcription factor 7-like 2 isoform X9

      Conserved Domains (2) summary
      cd01388
      Location:358 → 425
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    14. XM_044240535.1 → XP_044096470.1  transcription factor 7-like 2 isoform X12

      Conserved Domains (2) summary
      cd01388
      Location:358 → 425
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    15. XM_044240534.1 → XP_044096469.1  transcription factor 7-like 2 isoform X11

      Conserved Domains (2) summary
      cd01388
      Location:353 → 420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    16. XM_044240536.1 → XP_044096471.1  transcription factor 7-like 2 isoform X13

      Conserved Domains (2) summary
      cd01388
      Location:353 → 420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    17. XM_044240533.1 → XP_044096468.1  transcription factor 7-like 2 isoform X10

      Conserved Domains (2) summary
      cd01388
      Location:354 → 421
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    18. XM_044240538.1 → XP_044096473.1  transcription factor 7-like 2 isoform X15

      Conserved Domains (2) summary
      cd01388
      Location:349 → 416
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    19. XM_044240537.1 → XP_044096472.1  transcription factor 7-like 2 isoform X14

      Conserved Domains (2) summary
      cd01388
      Location:335 → 402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    20. XM_044240541.1 → XP_044096476.1  transcription factor 7-like 2 isoform X18

      Conserved Domains (2) summary
      cd01388
      Location:335 → 402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    21. XM_044240539.1 → XP_044096474.1  transcription factor 7-like 2 isoform X16

      Conserved Domains (2) summary
      cd01388
      Location:330 → 397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    22. XM_044240543.1 → XP_044096478.1  transcription factor 7-like 2 isoform X20

      Conserved Domains (2) summary
      cd01388
      Location:330 → 397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    23. XM_044240542.1 → XP_044096477.1  transcription factor 7-like 2 isoform X19

      Conserved Domains (2) summary
      cd01388
      Location:330 → 397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    24. XM_044240540.1 → XP_044096475.1  transcription factor 7-like 2 isoform X17

      Conserved Domains (2) summary
      cd01388
      Location:326 → 393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    25. XM_044240551.1 → XP_044096486.1  transcription factor 7-like 2 isoform X27

      Conserved Domains (2) summary
      cd01388
      Location:406 → 473
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 307
      CTNNB1_binding; N-terminal CTNNB1 binding

    26. XM_044240555.1 → XP_044096490.1  transcription factor 7-like 2 isoform X31

      Conserved Domains (2) summary
      cd01388
      Location:358 → 425
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    27. XM_044240553.1 → XP_044096488.1  transcription factor 7-like 2 isoform X29

      Conserved Domains (2) summary
      cd01388
      Location:353 → 420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    28. XM_044240552.1 → XP_044096487.1  transcription factor 7-like 2 isoform X28

      Conserved Domains (2) summary
      cd01388
      Location:377 → 444
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 283
      CTNNB1_binding; N-terminal CTNNB1 binding

    29. XM_044240554.1 → XP_044096489.1  transcription factor 7-like 2 isoform X30

      Conserved Domains (2) summary
      cd01388
      Location:335 → 402
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    30. XM_044240556.1 → XP_044096491.1  transcription factor 7-like 2 isoform X32

      Conserved Domains (2) summary
      cd01388
      Location:353 → 420
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    31. XM_044240557.1 → XP_044096492.1  transcription factor 7-like 2 isoform X33

      Conserved Domains (2) summary
      cd01388
      Location:349 → 416
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 259
      CTNNB1_binding; N-terminal CTNNB1 binding

    32. XM_044240558.1 → XP_044096493.1  transcription factor 7-like 2 isoform X34

      Conserved Domains (2) summary
      cd01388
      Location:330 → 397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    33. XM_044240560.1 → XP_044096495.1  transcription factor 7-like 2 isoform X36

      Conserved Domains (2) summary
      cd01388
      Location:330 → 397
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    34. XM_044240559.1 → XP_044096494.1  transcription factor 7-like 2 isoform X35

      Conserved Domains (2) summary
      cd01388
      Location:326 → 393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    35. XM_044240561.1 → XP_044096496.1  transcription factor 7-like 2 isoform X37

      Conserved Domains (2) summary
      cd01388
      Location:326 → 393
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:17 → 236
      CTNNB1_binding; N-terminal CTNNB1 binding

    36. XM_044240545.1 → XP_044096480.1  transcription factor 7-like 2 isoform X22

      UniProtKB/TrEMBL
      A0A8C7AIG3
      Conserved Domains (2) summary
      cd01388
      Location:274 → 341
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:101 → 175
      CTNNB1_binding; N-terminal CTNNB1 binding

    37. XM_044240546.1 → XP_044096481.1  transcription factor 7-like 2 isoform X23

      UniProtKB/TrEMBL
      A0A8C7AIG3
      Conserved Domains (1) summary
      cd01388
      Location:271 → 338
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    Nucleotide Protein
    Heading Accession and Version

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