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    PAK3 p21 (RAC1) activated kinase 3 [ Homo sapiens (human) ]

    Gene ID: 5063, updated on 5-May-2024

    Summary

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    Official Symbol
    PAK3provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:8592
    See related
    Ensembl:ENSG00000077264 MIM:300142; AllianceGenome:HGNC:8592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK
    Summary
    The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
    Expression
    Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xq23
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (110944397..111227361)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (109392559..109675560)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110187625..110470589)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:109911493-109912258 Neighboring gene M6PR pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29856 Neighboring gene chordin like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110065211-110065764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:110187999-110188834 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110207796-110208396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110254037-110254537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29857 Neighboring gene NANOG hESC enhancer GRCh37_chrX:110438658-110439159 Neighboring gene FCF1 pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:110489468-110490667 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:110498437-110498970 Neighboring gene glutamate dehydrogenase 1 pseudogene 9 Neighboring gene calpain 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth. Magne N, et al. Cell Oncol (Dordr), 2021 Dec. PMID 34550532
    2. Novel PAK3 gene missense variant associated with two Chinese siblings with intellectual disability: a case report. Qian Y, et al. BMC Med Genet, 2020 Feb 12. PMID 32050918, Free PMC Article
    3. Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells. Ruan P, et al. Virus Genes, 2020 Apr. PMID 31897927
    4. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration. Duarte K, et al. Neurobiol Dis, 2020 Mar. PMID 31843706
    5. Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature. Nagy D, et al. Eur J Med Genet, 2020 Apr. PMID 31678216

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
      Title: PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
    2. The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
      Title: The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis.
    3. Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
      Title: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation.
    4. Prognostic significance of PAK family kinases in acute myeloid leukemia.
      Title: Prognostic significance of PAK family kinases in acute myeloid leukemia.
    5. PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
      Title: PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration.
    6. Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
      Title: Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
    7. Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
      Title: Further delineation of the phenotype of PAK3-associated x-linked intellectual disability: Identification of a novel missense mutation and review of literature.
    8. Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
      Title: Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
    9. PAK3 regulates the Akt-GSK3beta-beta-catenin signaling by acting as Ser(473)-Akt kinase in several pancreatic cancer cell lines, promoting cancer stem cell phenotypes.
      Title: p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells.
    10. We diagnosed two male siblings with developmental delays as having a PAK3 likely pathogenic variant. This finding expands the list of PAK3 gene mutations associated with neurodevelopmental disorders and provides further details on its clinical features
      Title: Novel PAK3 gene missense variant associated with two Chinese siblings with intellectual disability: a case report.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, X-linked 30
    MedGen: C0796237 OMIM: 300558 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686E11117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic spine morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in synapse organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 3
    Names
    adriamycin resistance-associated
    oligophrenin-3
    p21 (CDKN1A)-activated kinase 3
    p21 protein (Cdc42/Rac)-activated kinase 3
    NP_001121638.1
    NP_001121639.1
    NP_001121640.1
    NP_001121644.1
    NP_001121645.1
    NP_001311254.1
    NP_001311255.1
    NP_001311256.1
    NP_001311257.1
    NP_001311258.1
    NP_001311259.1
    NP_001311260.1
    NP_001311261.1
    NP_001311262.1
    NP_001311263.1
    NP_002569.1
    XP_005262189.1
    XP_005262190.1
    XP_006724717.1
    XP_006724718.1
    XP_011529264.1
    XP_011529270.1
    XP_011529271.1
    XP_011529273.1
    XP_016885046.1
    XP_016885047.1
    XP_016885048.1
    XP_016885049.1
    XP_016885052.1
    XP_047298102.1
    XP_047298103.1
    XP_047298104.1
    XP_047298105.1
    XP_047298106.1
    XP_054183121.1
    XP_054183122.1
    XP_054183123.1
    XP_054183124.1
    XP_054183125.1
    XP_054183126.1
    XP_054183127.1
    XP_054183128.1
    XP_054183129.1
    XP_054183130.1
    XP_054183131.1
    XP_054183132.1
    XP_054183133.1
    XP_054183134.1
    XP_054183135.1
    XP_054183136.1
    XP_054183137.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008288.2 RefSeqGene

      Range
      156907..288077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128166.3 → NP_001121638.1  serine/threonine-protein kinase PAK 3 isoform a

      See identical proteins and their annotated locations for NP_001121638.1

      Status: REVIEWED

      Source sequence(s)
      AK290504, AK315284, AL031117, BC117353, DB563607
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000410853.1, ENST00000446737.5
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    2. NM_001128167.3 → NP_001121639.1  serine/threonine-protein kinase PAK 3 isoform a

      See identical proteins and their annotated locations for NP_001121639.1

      Status: REVIEWED

      Source sequence(s)
      AK290504, AL031117, BC117353, DB563607
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000401982.1, ENST00000425146.5
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    3. NM_001128168.3 → NP_001121640.1  serine/threonine-protein kinase PAK 3 isoform b

      See identical proteins and their annotated locations for NP_001121640.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and contains two alternate in-frame exons compared to variant 1. The encoded isoform (b, also known as ab) is longer than isoform a.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48151.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:284 → 580
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 162
      PBD; P21-Rho-binding domain

    4. NM_001128172.2 → NP_001121644.1  serine/threonine-protein kinase PAK 3 isoform c

      See identical proteins and their annotated locations for NP_001121644.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has a shorter 5' UTR and contains an alternate in-frame exon compared to variant 1. It encodes isoform c which is longer than isoform a.
      Source sequence(s)
      AK290504, AL031117, AM943852, BC117353, DB563607
      Consensus CDS
      CCDS48152.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000389172.1, ENST00000417227.5
      Conserved Domains (2) summary
      cd06656
      Location:269 → 565
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 147
      PBD; P21-Rho-binding domain

    5. NM_001128173.3 → NP_001121645.1  serine/threonine-protein kinase PAK 3 isoform d

      See identical proteins and their annotated locations for NP_001121645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter and contains alternate in-frame exon compared to variant 1. It encodes isoform d (also known as b) which is longer than isoform a.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    6. NM_001324325.2 → NP_001311254.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL031117, AL117326, AL356578, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    7. NM_001324326.2 → NP_001311255.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    8. NM_001324327.2 → NP_001311256.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    9. NM_001324328.2 → NP_001311257.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000262836.4, ENST00000262836.6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    10. NM_001324329.2 → NP_001311258.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000361080.1, ENST00000372010.5
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    11. NM_001324330.2 → NP_001311259.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL031117, AL117326, AL356578, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    12. NM_001324331.2 → NP_001311260.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    13. NM_001324332.2 → NP_001311261.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    14. NM_001324333.2 → NP_001311262.1  serine/threonine-protein kinase PAK 3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS48153.1
      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    15. NM_001324334.2 → NP_001311263.1  serine/threonine-protein kinase PAK 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    16. NM_002578.5 → NP_002569.1  serine/threonine-protein kinase PAK 3 isoform a

      See identical proteins and their annotated locations for NP_002569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
      Source sequence(s)
      AK290504, AL031117, BC117353, DA022842, DA957724, DB563607
      Consensus CDS
      CCDS14554.1
      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000361077.4, ENST00000372007.10
      Conserved Domains (2) summary
      cd06656
      Location:248 → 544
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 126
      PBD; P21-Rho-binding domain

    RNA

    1. NR_136740.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    2. NR_136741.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    3. NR_136742.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    4. NR_136743.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    5. NR_136744.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    6. NR_136745.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    7. NR_136746.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      AL357774

    8. NR_136747.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) represents use of an alternate promoter and contains an alternate exon in the 3' region compared to variant 1.
      Source sequence(s)
      AL031117, AL117326, AL357774

    9. NR_136748.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is shorter at the 5' end and contains an alternate exon in the 3' region compared to variant 1.
      Source sequence(s)
      AL031117, AL357774, BC143544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      110944397..111227361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442148.1 → XP_047298104.1  serine/threonine-protein kinase PAK 3 isoform X4

    2. XM_047442149.1 → XP_047298105.1  serine/threonine-protein kinase PAK 3 isoform X4

    3. XM_017029557.2 → XP_016885046.1  serine/threonine-protein kinase PAK 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (2) summary
      cd06656
      Location:263 → 559
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 141
      PBD; P21-Rho-binding domain

    4. XM_011530968.3 → XP_011529270.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_011529270.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    5. XM_011530969.2 → XP_011529271.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_011529271.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    6. XM_017029559.2 → XP_016885048.1  serine/threonine-protein kinase PAK 3 isoform X3

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    7. XM_017029563.2 → XP_016885052.1  serine/threonine-protein kinase PAK 3 isoform X7

      UniProtKB/TrEMBL
      B2RCU6
      Related
      ENSP00000428921.1, ENST00000518291.6
      Conserved Domains (2) summary
      cd06656
      Location:284 → 580
      STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
      pfam00786
      Location:69 → 162
      PBD; P21-Rho-binding domain

    8. XM_047442147.1 → XP_047298103.1  serine/threonine-protein kinase PAK 3 isoform X3

    9. XM_011530962.2 → XP_011529264.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_011529264.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    10. XM_047442146.1 → XP_047298102.1  serine/threonine-protein kinase PAK 3 isoform X3

    11. XM_005262132.3 → XP_005262189.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_005262189.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    12. XM_005262133.4 → XP_005262190.1  serine/threonine-protein kinase PAK 3 isoform X3

      See identical proteins and their annotated locations for XP_005262190.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    13. XM_006724654.3 → XP_006724717.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_006724717.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    14. XM_017029558.2 → XP_016885047.1  serine/threonine-protein kinase PAK 3 isoform X3

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    15. XM_006724655.3 → XP_006724718.1  serine/threonine-protein kinase PAK 3 isoform X1

      See identical proteins and their annotated locations for XP_006724718.1

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:283 → 530
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:275 → 530
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain

    16. XM_017029560.2 → XP_016885049.1  serine/threonine-protein kinase PAK 3 isoform X3

      UniProtKB/TrEMBL
      B2RCU6
      Conserved Domains (3) summary
      smart00220
      Location:268 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06647
      Location:260 → 515
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:69 → 124
      PBD; P21-Rho-binding domain

    17. XM_011530971.3 → XP_011529273.1  serine/threonine-protein kinase PAK 3 isoform X6

      Conserved Domains (2) summary
      pfam00786
      Location:69 → 139
      PBD; P21-Rho-binding domain
      cl21453
      Location:262 → 292
      PKc_like; Protein Kinases, catalytic domain

    18. XM_047442150.1 → XP_047298106.1  serine/threonine-protein kinase PAK 3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      109392559..109675560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327159.1 → XP_054183134.1  serine/threonine-protein kinase PAK 3 isoform X4

    2. XM_054327160.1 → XP_054183135.1  serine/threonine-protein kinase PAK 3 isoform X4

    3. XM_054327152.1 → XP_054183127.1  serine/threonine-protein kinase PAK 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8

    4. XM_054327151.1 → XP_054183126.1  serine/threonine-protein kinase PAK 3 isoform X1

    5. XM_054327150.1 → XP_054183125.1  serine/threonine-protein kinase PAK 3 isoform X1

    6. XM_054327156.1 → XP_054183131.1  serine/threonine-protein kinase PAK 3 isoform X3

    7. XM_054327162.1 → XP_054183137.1  serine/threonine-protein kinase PAK 3 isoform X7

    8. XM_054327158.1 → XP_054183133.1  serine/threonine-protein kinase PAK 3 isoform X3

    9. XM_054327149.1 → XP_054183124.1  serine/threonine-protein kinase PAK 3 isoform X1

    10. XM_054327154.1 → XP_054183129.1  serine/threonine-protein kinase PAK 3 isoform X3

    11. XM_054327146.1 → XP_054183121.1  serine/threonine-protein kinase PAK 3 isoform X1

    12. XM_054327153.1 → XP_054183128.1  serine/threonine-protein kinase PAK 3 isoform X3

    13. XM_054327147.1 → XP_054183122.1  serine/threonine-protein kinase PAK 3 isoform X1

    14. XM_054327155.1 → XP_054183130.1  serine/threonine-protein kinase PAK 3 isoform X3

    15. XM_054327148.1 → XP_054183123.1  serine/threonine-protein kinase PAK 3 isoform X1

    16. XM_054327157.1 → XP_054183132.1  serine/threonine-protein kinase PAK 3 isoform X3

    17. XM_054327161.1 → XP_054183136.1  serine/threonine-protein kinase PAK 3 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75914.2 GenPept UniProtKB/Swiss-Prot:O75914

    Gene LinkOut

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