U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    LOC126862059 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:102197209-102198408 [ Homo sapiens (human) ]

    Gene ID: 126862059, updated on 10-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC126862059
    Gene description
    P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:102197209-102198408
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC126862059 in Genome Data Viewer
    Location:
    chromosome: 14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (101730872..101732071)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95966611..95967810)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102086475-102087282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102088484-102089040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102089041-102089597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102089661-102090174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102090175-102090686 Neighboring gene long intergenic non-protein coding RNA 2320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102132807-102133306 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102155672-102155835 Neighboring gene ribosomal protein L26 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102174026-102174796 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102184781-102184986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:102188573-102189513 Neighboring gene long intergenic non-protein coding RNA 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6102 Neighboring gene uncharacterized LOC107984658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6103 Neighboring gene protein phosphatase 2 regulatory subunit B'gamma Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9045 Neighboring gene uncharacterized LOC124903388 Neighboring gene RNA, U6 small nuclear 790, pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
    2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    General gene information

    Go to the top of the page Help

    Other Names

    • ATAC-STARR-seq lymphoblastoid active region 9043
    • ATAC-STARR-seq lymphoblastoid active region 9044

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_086557.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      101730872..101732071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      95966611..95967810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases