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    FLYWCH2 FLYWCH family member 2 [ Homo sapiens (human) ]

    Gene ID: 114984, updated on 9-Jun-2024

    Summary

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    Official Symbol
    FLYWCH2provided by HGNC
    Official Full Name
    FLYWCH family member 2provided by HGNC
    Primary source
    HGNC:HGNC:25178
    See related
    Ensembl:ENSG00000162076 AllianceGenome:HGNC:25178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen (RPKM 10.8), prostate (RPKM 8.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FLYWCH2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2883195..2899382)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2909827..2926022)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2933196..2949383)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2907556-2908156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908157-2908757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908758-2909357 Neighboring gene serine protease 22 Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:2955125-2955625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7084 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2962376-2962565 Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2974631-2975496 Neighboring gene ribosomal protein L23a pseudogene 86 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:2978151-2978660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2988192-2988805 Neighboring gene uncharacterized LOC105371055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3005307-3006228

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. Zhu X, et al. FASEB J, 2016 Feb. PMID 26472337
    2. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Scholz CC, et al. PLoS Biol, 2016 Jan. PMID 26752685, Free PMC Article
    3. An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase. Zhou Z, et al. iScience, 2022 Feb 18. PMID 35198878, Free PMC Article
    4. MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, et al. Mol Cell, 2018 Dec 6. PMID 30415952
    5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    FLYWCH family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142499.1 → NP_001135971.1  FLYWCH family member 2

      See identical proteins and their annotated locations for NP_001135971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL542248, BC014089, BG120460, CA413438, DB455461
      Consensus CDS
      CCDS10482.1
      UniProtKB/Swiss-Prot
      Q96CP2
      Related
      ENSP00000293981.6, ENST00000293981.10
      Conserved Domains (1) summary
      pfam15423
      Location:1 → 106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein

    2. NM_001142500.1 → NP_001135972.1  FLYWCH family member 2

      See identical proteins and their annotated locations for NP_001135972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC014089, BG120460, BI825861, CA413438, DB455461
      Consensus CDS
      CCDS10482.1
      UniProtKB/Swiss-Prot
      Q96CP2
      Conserved Domains (1) summary
      pfam15423
      Location:1 → 106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein

    3. NM_138439.3 → NP_612448.1  FLYWCH family member 2

      See identical proteins and their annotated locations for NP_612448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC014089, BG120460, CA413438, DB455461
      Consensus CDS
      CCDS10482.1
      UniProtKB/Swiss-Prot
      Q96CP2
      Related
      ENSP00000380159.3, ENST00000396958.8
      Conserved Domains (1) summary
      pfam15423
      Location:1 → 106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2883195..2899382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255078.6 → XP_005255135.1  FLYWCH family member 2 isoform X1

      See identical proteins and their annotated locations for XP_005255135.1

      UniProtKB/Swiss-Prot
      Q96CP2
      Conserved Domains (1) summary
      pfam15423
      Location:1 → 106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein

    2. XM_047433572.1 → XP_047289528.1  FLYWCH family member 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2909827..2926022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379508.1 → XP_054235483.1  FLYWCH family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q96CP2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96CP2.1 GenPept UniProtKB/Swiss-Prot:Q96CP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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