EIF3C eukaryotic translation initiation factor 3 subunit C [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF3Cprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 3 subunit Cprovided by HGNC
Primary source: HGNC:HGNC:3279
See related: Ensembl:ENSG00000184110 MIM:603916; AllianceGenome:HGNC:3279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EIF3CL; EIF3S8; eIF3-p110
Summary: Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 16p11.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (28688558..28735730)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (28969279..29016311)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (28699879..28747051)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complement factor H attenuates TNF-alpha-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
Title: Complement factor H attenuates TNF-α-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
Title: circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
Title: Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
Title: ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
Title: Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
circ_0067934 promotes cervical cancer progression via miR-545/EIF3C axis.
Title: Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis.
eIF3C expression was upregulated in renal cell carcinoma (RCC) tissues and cell lines. Depletion of eIF3C reduced tumor cell proliferation and arrested them at the G1 stage, thus promoting their apoptosis in vitro. Depletion of eIF3C also inhibited the formation and growth of tumor cell xenografts in nude mice. Study demonstrated that upregulated eIF3C expression contributed to the development and progression of RCC.
Title: Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma.
Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
EIF3C overexpression was correlated to age and tumor stage in prostate cancer patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Phosphorylation level of PI3K and Akt and total NF-kappaB and Myc decreased after EIF3C knockdown. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-kappaB signaling pathway in PC3...
Title: The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer.
In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity.
Title: Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at five new loci associated with early-onset inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

D16S2553E (e-PCR)
- UniSTS:151642

L17877 (e-PCR)
- UniSTS:61334

SGC31754 (e-PCR)
- UniSTS:43469

Clone Names

FLJ53378, FLJ54400, FLJ54404, FLJ55450, FLJ55750, FLJ78287, MGC189737, MGC189744

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	IC Inferred by Curator more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mRNA binding	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of translation	IPI Inferred from Physical Interaction more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IC Inferred by Curator more info	PubMed
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit C

Names: cell migration-inducing protein 17; eIF3 p110; eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3, subunit 8 (110kD); eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037808.2 → NP_001032897.1 eukaryotic translation initiation factor 3 subunit C isoform a

See identical proteins and their annotated locations for NP_001032897.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).

Source sequence(s)

AC145285, AL045958, BC001571, BC071705, DC341554

Consensus CDS

CCDS10638.1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7

Related

ENSP00000378953.1, ENST00000395587.5

Conserved Domains (2) summary

smart00088
Location:778 → 866

PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

pfam05470
Location:29 → 705

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
NM_001199142.1 → NP_001186071.1 eukaryotic translation initiation factor 3 subunit C isoform a

See identical proteins and their annotated locations for NP_001186071.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).

Source sequence(s)

AA679705, AK292155

Consensus CDS

CCDS10638.1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7

Related

ENSP00000457963.1, ENST00000566501.5

Conserved Domains (2) summary

smart00088
Location:778 → 866

PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

pfam05470
Location:29 → 705

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
NM_001267574.2 → NP_001254503.1 eukaryotic translation initiation factor 3 subunit C isoform a

See identical proteins and their annotated locations for NP_001254503.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).

Source sequence(s)

AC145285, AK000739, AL045958, BC001571, DC341554

Consensus CDS

CCDS10638.1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7

Related

ENSP00000457418.1, ENST00000566866.5

Conserved Domains (2) summary

smart00088
Location:778 → 866

PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

pfam05470
Location:29 → 705

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
NM_001286478.1 → NP_001273407.1 eukaryotic translation initiation factor 3 subunit C isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC145285, AK303790, BC001571, DC341554

Consensus CDS

CCDS66993.1

UniProtKB/TrEMBL

A1KYQ7

Related

ENSP00000456416.1, ENST00000564243.5

Conserved Domains (2) summary

smart00753
Location:768 → 856

PAM; PCI/PINT associated module

pfam05470
Location:29 → 695

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
NM_003752.5 → NP_003743.1 eukaryotic translation initiation factor 3 subunit C isoform a

See identical proteins and their annotated locations for NP_003743.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).

Source sequence(s)

BC001571, DC341554

Consensus CDS

CCDS10638.1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7

Related

ENSP00000332604.7, ENST00000331666.11

Conserved Domains (2) summary

smart00088
Location:778 → 866

PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

pfam05470
Location:29 → 705

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

28688558..28735730

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047434828.1 → XP_047290784.1 eukaryotic translation initiation factor 3 subunit C isoform X1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7
XM_047434827.1 → XP_047290783.1 eukaryotic translation initiation factor 3 subunit C isoform X1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7
XM_017023814.3 → XP_016879303.1 eukaryotic translation initiation factor 3 subunit C isoform X2

UniProtKB/TrEMBL

A1KYQ7
XM_047434829.1 → XP_047290785.1 eukaryotic translation initiation factor 3 subunit C isoform X3

UniProtKB/TrEMBL

B3KNZ4

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

28969279..29016311

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314249.1 → XP_054170224.1 eukaryotic translation initiation factor 3 subunit C isoform X1

UniProtKB/Swiss-Prot

A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

UniProtKB/TrEMBL

A1KYQ7
XM_054314250.1 → XP_054170225.1 eukaryotic translation initiation factor 3 subunit C isoform X3

UniProtKB/TrEMBL

B3KNZ4