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    gpbar1 G protein-coupled bile acid receptor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 797190, updated on 11-Apr-2024

    Summary

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    Official Symbol
    gpbar1provided by ZNC
    Official Full Name
    G protein-coupled bile acid receptor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120315-1
    See related
    Ensembl:ENSDARG00000023302 AllianceGenome:ZFIN:ZDB-GENE-120315-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human GPBAR1 (G protein-coupled bile acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See gpbar1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (47961382..47970871)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (48264230..48273458)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein K02A2.6-like Neighboring gene tensin 1b Neighboring gene zgc:92380 Neighboring gene actin related protein 2/3 complex, subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Xiong F, et al. Dev Comp Immunol, 2021 Mar. PMID 33285186
    2. A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host. Enya S, et al. Dis Model Mech, 2018 May 3. PMID 29592890, Free PMC Article
    3. Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Wu X, et al. Antibiotics (Basel), 2021 Jul 15. PMID 34356784, Free PMC Article
    4. Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Gebauer JM, et al. Matrix Biol, 2016 Jan. PMID 26235539
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The function of zebrafish gpbar1 in antiviral response and lipid metabolism.
      Title: The function of zebrafish gpbar1 in antiviral response and lipid metabolism.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled bile acid receptor 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      47961382..47970871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357898.2 → XP_017213387.1  G-protein coupled bile acid receptor 1-like isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z8Q0, F1R4Y8
      Related
      ENSDARP00000060589.6, ENSDART00000060590.6

    2. XM_009304972.3 → XP_009303247.3  G-protein coupled bile acid receptor 1-like isoform X1

      UniProtKB/TrEMBL
      A0A8M3AWA6
      Related
      ENSDARP00000151679.1, ENSDART00000183345.1
      Conserved Domains (1) summary
      cd15905
      Location:29 → 326
      7tmA_GPBAR1; G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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