rnasel2 ribonuclease like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rnasel2provided by ZNC
Official Full Name: ribonuclease like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-420
See related: Ensembl:ENSDARG00000043196 AllianceGenome:ZFIN:ZDB-GENE-050208-420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RNase 2; rnasel5; Dr-RNase2; RNase ZF-2; zf-rnase-2; si:ch211-139g14.6
Summary: Enables ribonuclease activity. Acts upstream of or within angiogenesis; defense response to Gram-negative bacterium; and defense response to Gram-positive bacterium. Is expressed in gut; heart; intestine; and liver. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to several human genes including ANG (angiogenin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (6293563..6294366)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (6263717..6264520)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IC Inferred by Curator more info	PubMed
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribonuclease like 2

Names: RNase ZF-2b; ribonuclease like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100105.3 → NP_001093575.1 ribonuclease like 2 precursor

See identical proteins and their annotated locations for NP_001093575.1

Status: VALIDATED

Source sequence(s)

AL928685

UniProtKB/TrEMBL

A5HAK1, B2GTW3, F6PAA7

Related

ENSDARP00000063415.4, ENSDART00000063416.5

Conserved Domains (1) summary

cd06265
Location:27 → 141

RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have been ...