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    Mbnl3 muscleblind-like splicing regulator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302492, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Mbnl3provided by RGD
    Official Full Name
    muscleblind-like splicing regulator 3provided by RGD
    Primary source
    RGD:1565834
    See related
    Ensembl:ENSRNOG00000002487 AllianceGenome:RGD:1565834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565834
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human MBNL3 (muscleblind like splicing regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 138.1), Thymus (RPKM 77.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mbnl3 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (135526256..135621499, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (130641942..130737179, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (138378674..138473365, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit gamma, pseudogene 2 Neighboring gene RAP2C, member of RAS oncogene family Neighboring gene small nucleolar RNA SNORA48 Neighboring gene high mobility group protein B4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR. Squillace RM, et al. Dev Biol, 2002 Oct 1. PMID 12297108
    2. Muscleblind proteins regulate alternative splicing. Ho TH, et al. EMBO J, 2004 Aug 4. PMID 15257297, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    muscleblind-like protein 3
    Names
    muscleblind-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106949.1 → NP_001100419.1  muscleblind-like protein 3

      See identical proteins and their annotated locations for NP_001100419.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473991
      UniProtKB/TrEMBL
      A6JMT4, D3ZQV3
      Related
      ENSRNOP00000039018.3, ENSRNOT00000043258.4
      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      135526256..135621499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279911.1 → XP_063135981.1  muscleblind-like protein 3 isoform X18

    2. XM_063279910.1 → XP_063135980.1  muscleblind-like protein 3 isoform X17

    3. XM_063279909.1 → XP_063135979.1  muscleblind-like protein 3 isoform X16

    4. XM_063279908.1 → XP_063135978.1  muscleblind-like protein 3 isoform X15

    5. XM_039099616.2 → XP_038955544.1  muscleblind-like protein 3 isoform X12

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    6. XM_063279907.1 → XP_063135977.1  muscleblind-like protein 3 isoform X11

    7. XM_063279906.1 → XP_063135976.1  muscleblind-like protein 3 isoform X9

    8. XM_039099609.2 → XP_038955537.1  muscleblind-like protein 3 isoform X3

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    9. XM_039099613.2 → XP_038955541.1  muscleblind-like protein 3 isoform X7

      UniProtKB/TrEMBL
      A6JMT4, D3ZQV3
      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    10. XM_039099611.2 → XP_038955539.1  muscleblind-like protein 3 isoform X5

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    11. XM_039099620.2 → XP_038955548.1  muscleblind-like protein 3 isoform X14

      UniProtKB/TrEMBL
      A0A8I6GLQ8
      Conserved Domains (1) summary
      smart00356
      Location:80 → 104
      ZnF_C3H1; zinc finger

    12. XM_039099622.2 → XP_038955550.1  muscleblind-like protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6GLQ8
      Related
      ENSRNOP00000095651.1
      Conserved Domains (1) summary
      smart00356
      Location:80 → 104
      ZnF_C3H1; zinc finger

    13. XM_039099615.2 → XP_038955543.1  muscleblind-like protein 3 isoform X10

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    14. XM_039099614.2 → XP_038955542.1  muscleblind-like protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZQQ7
      Related
      ENSRNOP00000080997.1
      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    15. XM_039099612.2 → XP_038955540.1  muscleblind-like protein 3 isoform X6

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    16. XM_039099610.2 → XP_038955538.1  muscleblind-like protein 3 isoform X4

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    17. XM_039099608.2 → XP_038955536.1  muscleblind-like protein 3 isoform X2

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    18. XM_039099606.2 → XP_038955534.1  muscleblind-like protein 3 isoform X1

      Conserved Domains (1) summary
      smart00356
      Location:176 → 200
      ZnF_C3H1; zinc finger

    19. XM_039099617.2 → XP_038955545.1  muscleblind-like protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6GLQ8
      Conserved Domains (1) summary
      smart00356
      Location:80 → 104
      ZnF_C3H1; zinc finger

    20. XM_039099618.2 → XP_038955546.1  muscleblind-like protein 3 isoform X13

      UniProtKB/TrEMBL
      A0A8I6GLQ8
      Conserved Domains (1) summary
      smart00356
      Location:80 → 104
      ZnF_C3H1; zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version

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