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    Zfp81 zinc finger protein 81 [ Mus musculus (house mouse) ]

    Gene ID: 224694, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp81provided by MGI
    Official Full Name
    zinc finger protein 81provided by MGI
    Primary source
    MGI:MGI:1890752
    See related
    Ensembl:ENSMUSG00000003929 AllianceGenome:MGI:1890752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp78; KRAB13; Hszfp36; C330034P10Rik; D330034E10Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 4.8), CNS E14 (RPKM 4.5) and 18 other tissues See more
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    Genomic context

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    See Zfp81 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33548316..33577874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33329342..33358896, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily H member 28 Neighboring gene STARR-positive B cell enhancer mm9_chr17:33426236-33426537 Neighboring gene zinc finger protein 955B Neighboring gene zinc finger protein 422, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr17:33495732-33496033 Neighboring gene zinc finger protein 101 Neighboring gene actin-like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
    4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 81
    Names
    ZFP-36 zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207541.1 → NP_997424.1  zinc finger protein 81

      Status: VALIDATED

      Source sequence(s)
      AK135853, BB143786
      Consensus CDS
      CCDS37564.1
      UniProtKB/TrEMBL
      B8JJZ7
      Related
      ENSMUSP00000050728.9, ENSMUST00000054072.9
      Conserved Domains (5) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      COG5048
      Location:277 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:488 → 513
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33548316..33577874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249699.2 → XP_030105559.1  zinc finger protein 81 isoform X2

      Related
      ENSMUSP00000157222.2, ENSMUST00000234016.2
      Conserved Domains (3) summary
      COG5048
      Location:213 → 373
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:424 → 449
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030249697.2 → XP_030105557.1  zinc finger protein 81 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:245 → 405
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:456 → 481
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030249698.1 → XP_030105558.1  zinc finger protein 81 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:245 → 405
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332 → 352
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:456 → 481
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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