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    PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [ Felis catus (domestic cat) ]

    Gene ID: 101094910, updated on 8-Mar-2024

    Summary

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    Official Symbol
    PFKFB1
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
    Primary source
    VGNC:VGNC:68803
    See related
    EnsemblRapid:ENSFCTG00005004196
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) X NC_058386.1 (47790368..47926803, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) X NC_018741.3 (47941804..48079099, complement)

    Chromosome X - NC_058386.1Genomic Context describing neighboring genes Neighboring gene elongation factor 1-alpha 1-like Neighboring gene trophinin Neighboring gene small nucleolar RNA SNORA11 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2 Neighboring gene 5'-aminolevulinate synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058386.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      47790368..47926803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011291760.3 → XP_011290062.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X8

      UniProtKB/TrEMBL
      A0A337S3U5, A0A337SAJ9
      Related
      ENSFCTP00005007035.1, ENSFCTT00005011291.1
      Conserved Domains (2) summary
      pfam00300
      Location:189 → 372
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:10 → 186
      6PF2K; 6-phosphofructo-2-kinase

    2. XM_019823870.2 → XP_019679429.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X7

      UniProtKB/TrEMBL
      A0A337SAJ9
      Conserved Domains (2) summary
      pfam01591
      Location:16 → 192
      6PF2K; 6-phosphofructo-2-kinase
      pfam00300
      Location:195 → 381
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    3. XM_006943769.4 → XP_006943831.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X2

      UniProtKB/TrEMBL
      A0A337SAJ9
      Related
      ENSFCTP00005007030.1, ENSFCTT00005011285.1
      Conserved Domains (3) summary
      pfam00300
      Location:237 → 420
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:17 → 234
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:27 → 181
      AAA_33; AAA domain

    4. XM_006943770.4 → XP_006943832.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

      UniProtKB/TrEMBL
      A0A337SAJ9, A0A337SUA4
      Related
      ENSFCTP00005007033.1, ENSFCTT00005011288.1
      Conserved Domains (3) summary
      pfam00300
      Location:231 → 414
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:7 → 228
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:21 → 175
      AAA_33; AAA domain

    5. XM_045051370.1 → XP_044907305.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X5

      UniProtKB/TrEMBL
      A0A337SAJ9
      Conserved Domains (2) summary
      COG0406
      Location:212 → 386
      PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
      cl17190
      Location:84 → 119
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    6. XM_045051369.1 → XP_044907304.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X4

      UniProtKB/TrEMBL
      A0A337SAJ9
      Related
      ENSFCTP00005007024.1, ENSFCTT00005011279.1
      Conserved Domains (1) summary
      PTZ00322
      Location:36 → 413
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

    7. XM_004000551.5 → XP_004000600.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X1

      UniProtKB/TrEMBL
      A0A337SAJ9, M3VVL9
      Related
      ENSFCTP00005007027.1, ENSFCTT00005011282.1
      Conserved Domains (3) summary
      pfam00300
      Location:257 → 440
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:33 → 254
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:47 → 201
      AAA_33; AAA domain

    8. XM_023248938.2 → XP_023104706.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X6

      UniProtKB/TrEMBL
      A0A337SAJ9
      Related
      ENSFCTP00005007019.1, ENSFCTT00005011274.1
      Conserved Domains (1) summary
      PTZ00322
      Location:1 → 411
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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