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    Smap1 small ArfGAP 1 [ Mus musculus (house mouse) ]

    Gene ID: 98366, updated on 24-Apr-2022

    Summary

    Official Symbol
    Smap1provided by MGI
    Official Full Name
    small ArfGAP 1provided by MGI
    Primary source
    MGI:MGI:2138261
    See related
    Ensembl:ENSMUSG00000026155 AllianceGenome:MGI:2138261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI462175; 1700056O10Rik; 4921514B13Rik; 4921525H11Rik
    Summary
    Enables GTPase activator activity and clathrin binding activity. Acts upstream of or within positive regulation of erythrocyte differentiation and regulation of clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in embryo. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Smap1 in Genome Data Viewer
    Location:
    1; 1 A5
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (23883906..23961462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (23844825..23922381, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (23852466..23929128, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 28822 Neighboring gene beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene family with sequence similarity 135, member A Neighboring gene predicted gene, 30756

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    stromal membrane-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290683.1NP_001277612.1  stromal membrane-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001277612.1

      Status: VALIDATED

      Source sequence(s)
      AI846174, AK006817, AK014966, AK132868, BC080286
      Consensus CDS
      CCDS69870.1
      UniProtKB/Swiss-Prot
      Q91VZ6
      UniProtKB/TrEMBL
      D3YVX4
      Related
      ENSMUSP00000117875.2, ENSMUST00000129254.8
    2. NM_001357395.1NP_001344324.1  stromal membrane-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121857, AC123790, AC153649
      Conserved Domains (2) summary
      pfam01412
      Location:20120
      ArfGap; Putative GTPase activating protein for Arf
      pfam09606
      Location:343451
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    3. NM_028534.3NP_082810.1  stromal membrane-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_082810.1

      Status: VALIDATED

      Source sequence(s)
      AI846174, AK014966, AK132868, BC080286, BC100537, CJ062632
      Consensus CDS
      CCDS14851.1
      UniProtKB/Swiss-Prot
      Q91VZ6
      Related
      ENSMUSP00000027339.8, ENSMUST00000027339.14
      Conserved Domains (1) summary
      pfam01412
      Location:20120
      ArfGap; Putative GTPase activating protein for Arf

    RNA

    1. NR_110972.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121857, AK132868, BE631392
      Related
      ENSMUST00000149737.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      23883906..23961462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243880.2XP_030099740.1  stromal membrane-associated protein 1 isoform X1

      Conserved Domains (1) summary
      cl28907
      Location:135
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)