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    CCR6 C-C motif chemokine receptor 6 [ Homo sapiens (human) ]

    Gene ID: 1235, updated on 11-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6.

    Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6.
    Höhne K, Wagenknecht A, Maier C, Engelhard P, Goldmann T, Schließmann SJ, Plönes T, Trepel M, Eibel H, Müller-Quernheim J, Zissel G., Free PMC Article

    02/15/2024
    Role of the CCL20/CCR6 axis in tubular epithelial cell injury: Kidney-specific translational insights from acute kidney injury to chronic kidney disease.

    Role of the CCL20/CCR6 axis in tubular epithelial cell injury: Kidney-specific translational insights from acute kidney injury to chronic kidney disease.
    Yoo KD, Yu MY, Kim KH, Lee S, Park E, Kang S, Lim DH, Lee Y, Song J, Kown S, Kim YC, Kim DK, Lee JS, Kim YS, Yang SH.

    01/11/2024
    Increased gene expression of CCR6 and RORgammat in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti-cyclic citrullinated peptide and disease activity.

    Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti-cyclic citrullinated peptide and disease activity.
    Roghani SA, Lotfi R, Soroush MG, Khorasanizadeh A, Feizollahi P, Assar S, Soufivand P, Pournazari M, Mohammadi Kish Z, Taghadosi M., Free PMC Article

    01/3/2024
    Clinical Significance of the Pre-Transplant CXCR3 and CCR6 Expression on T Cells In Kidney Graft Recipients.

    Clinical Significance of the Pre-Transplant CXCR3 and CCR6 Expression on T Cells In Kidney Graft Recipients.
    Alfaro R, Llorente S, Gonzalez-Martínez G, Jimenez-Coll V, Martínez-Banaclocha H, Galián JA, Botella C, Moya-Quiles MR, de la Peña-Moral J, Minguela A, Legaz I, Muro M.

    03/15/2023
    SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation.

    SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation.
    Hanna DN, Smith PM, Novitskiy SV, Washington MK, Zi J, Weaver CJ, Hamaamen JA, Lewis KB, Zhu J, Yang J, Liu Q, Beauchamp RD, Means AL., Free PMC Article

    10/29/2022
    CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development.

    CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development.
    Korona B, Korona D, Zhao W, Wotherspoon AC, Du MQ., Free PMC Article

    06/11/2022
    rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis.

    rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis.
    Hitomi Y, Aiba Y, Ueno K, Nishida N, Kawai Y, Kawashima M, Yasunami M, Gervais O, Ito M, Cordell HJ, Mells GF, Nagasaki M, Tokunaga K, Tsuiji M, Nakamura M.

    03/19/2022
    Glycogen synthase kinase 3beta/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO.

    Glycogen synthase kinase 3β/CCR6-positive bone marrow cells correlate with disease activity in multicentric Castleman disease-TAFRO.
    Abe N, Kono M, Kono M, Ohnishi N, Sato T, Tarumi M, Yoshimura M, Sato T, Karino K, Shimizu Y, Fujieda Y, Kato M, Hasebe R, Oku K, Murakami M, Atsumi T.

    03/12/2022
    Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.

    Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.
    Kfoury Y, Baryawno N, Severe N, Mei S, Gustafsson K, Hirz T, Brouse T, Scadden EW, Igolkina AA, Kokkaliaris K, Choi BD, Barkas N, Randolph MA, Shin JH, Saylor PJ, Scadden DT, Sykes DB, Kharchenko PV, as part of the Boston Bone Metastases Consortium., Free PMC Article

    01/8/2022
    Amino terminal recognition by a CCR6 chemokine receptor antibody blocks CCL20 signaling and IL-17 expression via beta-arrestin.

    Amino terminal recognition by a CCR6 chemokine receptor antibody blocks CCL20 signaling and IL-17 expression via β-arrestin.
    Gómez-Melero S, García-Maceira FI, García-Maceira T, Luna-Guerrero V, Montero-Peñalvo G, Túnez-Fiñana I, Paz-Rojas E., Free PMC Article

    01/1/2022
    Endothelial CCR6 expression due to FLI1 deficiency contributes to vasculopathy associated with systemic sclerosis.

    Endothelial CCR6 expression due to FLI1 deficiency contributes to vasculopathy associated with systemic sclerosis.
    Ikawa T, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y., Free PMC Article

    01/1/2022
    Reduced CCR6(+)IL-17A(+)Treg Cells in Blood and CCR6-Dependent Accumulation of IL-17A(+)Treg Cells in Lungs of Patients With Allergic Asthma.

    Reduced CCR6(+)IL-17A(+)Treg Cells in Blood and CCR6-Dependent Accumulation of IL-17A(+)Treg Cells in Lungs of Patients With Allergic Asthma.
    Shen X, Zhang H, Xie H, Chen L, Li S, Zheng J, Chai R, Wang Z, Zang Y, He S., Free PMC Article

    12/25/2021
    CCL20-CCR6 axis directs sperm-oocyte interaction and its dysregulation correlates/associates with male infertilitydouble dagger.

    CCL20-CCR6 axis directs sperm-oocyte interaction and its dysregulation correlates/associates with male infertility‡.
    Duan YG, Wehry UP, Buhren BA, Schrumpf H, Oláh P, Bünemann E, Yu CF, Chen SJ, Müller A, Hirchenhain J, Lierop A, Novak N, Cai ZM, Krüssel JS, Schuppe HC, Haidl G, Gerber PA, Allam JP, Homey B.

    10/16/2021
    CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response.

    CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein-Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response.
    Lee DSW, Yam JY, Grasmuck C, Dasoveanu D, Michel L, Ward LA, Rojas OL, Zandee S, Bourbonnière L, Ramaglia V, Bar-Or A, Prat A, Gommerman JL.

    09/25/2021
    CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus.

    CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus.
    Lee AY, Körner H.

    08/28/2021
    Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma.

    Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma.
    Huang Q, Zhang F, Fu H, Shen J., Free PMC Article

    08/21/2021
    Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy.

    Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy.
    Jia C, Ke-Hong C, Fei X, Huan-Zi D, Jie Y, Li-Ming W, Xiao-Yue W, Jian-Guo Z, Ya-Ni H.

    08/14/2021
    A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population.

    A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population.
    Zhang YM, Liu XZ, Zhou XJ, Liu LJ, Shi SF, Hou P, Lv JC, Zhang H., Free PMC Article

    07/3/2021
    Enrichment of CCR6(+) CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19.

    Enrichment of CCR6(+) CD8(+) T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19.
    Saris A, Reijnders TDY, Reijm M, Hollander JC, de Buck K, Schuurman AR, Duitman J, Heunks L, Aman J, Bogaard HJ, Nossent EJ, van der Poll T, Bontkes HJ, Amsterdam UMC COVID study group., Free PMC Article

    06/19/2021
    Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data.

    Association of RASSF1A, DCR2, and CASP8 Methylation with Survival in Neuroblastoma: A Pooled Analysis Using Reconstructed Individual Patient Data.
    Hassan WM, Bakry MS, Siepmann T, Illigens B., Free PMC Article

    06/19/2021
    Eomes promotes esophageal carcinoma progression by recruiting Treg cells through the CCL20-CCR6 pathway.

    Eomes promotes esophageal carcinoma progression by recruiting Treg cells through the CCL20-CCR6 pathway.
    Lian J, Liu S, Yue Y, Yang Q, Zhang Z, Yang S, Zhang Y., Free PMC Article

    03/6/2021
    Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.

    Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.
    Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H., Free PMC Article

    08/29/2020
    Differential expression of CXCR3 and CCR6 on CD4(+) T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

    Differential expression of CXCR3 and CCR6 on CD4(+) T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.
    Silveira-Mattos PS, Narendran G, Akrami K, Fukutani KF, Anbalagan S, Nayak K, Subramanyam S, Subramani R, Vinhaes CL, Souza DO, Antonelli LR, Satagopan K, Porter BO, Sher A, Swaminathan S, Sereti I, Andrade BB., Free PMC Article

    08/22/2020
    Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6(+)B helper T cells in systemic lupus erythematosus.

    Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6(+)B helper T cells in systemic lupus erythematosus.
    Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M, Grassi F, Meroni PL, Flavell RA, Geginat J., Free PMC Article

    08/15/2020
    Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis.

    Cisplatin-stimulated macrophages promote ovarian cancer migration via the CCL20-CCR6 axis.
    Liu W, Wang W, Wang X, Xu C, Zhang N, Di W.

    08/15/2020
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