| KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway. | KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway.
Li Y, Wang Y, Zou Q, Li S, Zhang F. | 06/29/2023 |
| miR-324-5p promotes adipocyte differentiation and lipid droplet accumulation by targeting Krueppel-like factor 3 (KLF3). | miR-324-5p promotes adipocyte differentiation and lipid droplet accumulation by targeting Krueppel-like factor 3 (KLF3).
Zhou X, Shi X, Wang J, Zhang X, Xu Y, Liu Y, Li X, Yang G. | 03/6/2021 |
| Kruppel-like factor 3 (KLF3) suppresses NF-kappaB-driven inflammation in mice. | Krüppel-like factor 3 (KLF3) suppresses NF-κB-driven inflammation in mice.
Knights AJ, Yang L, Shah M, Norton LJ, Green GS, Stout ES, Vohralik EJ, Crossley M, Quinlan KGR., Free PMC Article | 12/26/2020 |
| KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells. | KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells.
Hao J, Yang X, Zhang C, Zhang XT, Shi M, Wang SH, Mi L, Zhao YT, Cao H, Wang Y., Free PMC Article | 11/21/2020 |
| miR-20a-5p promotes adipocyte differentiation from bone marrow-derived stromal cells by targeting and negatively regulating Klf3 in the early phase during the procedure of adipogenesis. | miR-20a-5p promotes adipogenic differentiation of murine bone marrow stromal cells via targeting Kruppel-like factor 3.
Zhu E, Zhang J, Zhou J, Yuan H, Zhao W, Wang B. | 09/14/2019 |
| KLF1 and KLF3 bind common as well as unique sites within the erythroid cell genome. | Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.
Ilsley MD, Gillinder KR, Magor GW, Huang S, Bailey TL, Crossley M, Perkins AC., Free PMC Article | 12/2/2017 |
| mechanistic insights into the regulation of Lgals3, demonstrating that C-terminal binding protein (CtBP) is required to drive optimal KLF3-mediated silencing. | Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).
Knights AJ, Yik JJ, Mat Jusoh H, Norton LJ, Funnell AP, Pearson RC, Bell-Anderson KS, Crossley M, Quinlan KG., Free PMC Article | 05/13/2017 |
| Cineromycin B inhibited adipocyte differentiation in 3T3-L1 cells mainly via upregulation of KLF2 and KLF3 mRNA expression at an early stage of the differentiation. | Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like factors 2 and 3.
Matsuo H, Kondo Y, Kawasaki T, Imamura N. | 10/31/2015 |
| Phosphorylation of KLF3 and CtBP2 by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3. | Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.
Dewi V, Kwok A, Lee S, Lee MM, Tan YM, Nicholas HR, Isono K, Wienert B, Mak KS, Knights AJ, Quinlan KG, Cordwell SJ, Funnell AP, Pearson RC, Crossley M., Free PMC Article | 06/6/2015 |
| KLF3 acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation. | Leukocyte β7 integrin targeted by Krüppel-like factors.
Alles M, Turchinovich G, Zhang P, Schuh W, Agenès F, Kirberg J. | 10/25/2014 |
| We conclude that KLF3 plays diverse and important roles in cardiovascular development and function in mice. | ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.
Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL., Free PMC Article | 01/11/2014 |
| KLF3 binds the Fam132a promoter in vitro and in vivo and that this leads to repression of promoter activity. Fam132a is significantly upregulated in the absence of KLF3. | Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).
Bell-Anderson KS, Funnell AP, Williams H, Mat Jusoh H, Scully T, Lim WF, Burdach JG, Mak KS, Knights AJ, Hoy AJ, Nicholas HR, Sainsbury A, Turner N, Pearson RC, Crossley M., Free PMC Article | 10/19/2013 |
| KLF3 and KLF8 have overlapping roles in vivo and participate in the silencing of embryonic globin expression during development. | Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.
Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T, Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam PP, Pearson RC, Crossley M., Free PMC Article | 09/21/2013 |
| IL-17 suppresses expression of PPARgamma, C/EBPalpha, KLF15, a pro-adipogenic transcription factor, and enhances expression of KLF2 and KLF3, which are anti-adipogenic. | IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors.
Ahmed M, Gaffen SL., Free PMC Article | 08/31/2013 |
| KLF3 is a feedback repressor that counters the activity of EKLF at selected target genes to achieve normal erythropoiesis | The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo.
Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, Pearson RC, Crossley M., Free PMC Article | 10/20/2012 |
| we concluded that KLF3 is a transcriptional repressor for wee1 gene. | Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements.
Kitamura T, Suzuki H, Tamura TA. | 02/18/2012 |
| KLF3 is a driving force toward marginal zone B-cell maturation. | Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3).
Turchinovich G, Vu TT, Frommer F, Kranich J, Schmid S, Alles M, Loubert JB, Goulet JP, Zimber-Strobl U, Schneider P, Bachl J, Pearson R, Crossley M, Agenès F, Kirberg J. | 07/2/2011 |
| KLF3 is an important regulator of several biological processes, including adipogenesis, erythropoiesis, and B cell development. (Review) | The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).
Pearson RC, Funnell AP, Crossley M. | 06/25/2011 |
| role for KLF3 in muscle gene regulation and an alternate mechanism for transcriptional regulation by SRF via its recruitment to KLF binding sites | KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites.
Himeda CL, Ranish JA, Pearson RC, Crossley M, Hauschka SD., Free PMC Article | 07/19/2010 |
| Klf8 is repressed by Klf3 and activated by Klf1 in vivo. | A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
Eaton SA, Funnell AP, Sue N, Nicholas H, Pearson RC, Crossley M., Free PMC Article | 01/21/2010 |
| basic Kruppel-like factor gene (Klf3) has a role with CtBP in adipogenesis | Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.
Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M., Free PMC Article | 01/21/2010 |
| in erythroid tissues basic Kruppel-like factor (Bklf/Klf3) expression is highly dependent on another family member, erythroid Kruppel-like factor (Eklf/Klf1) | Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.
Funnell AP, Maloney CA, Thompson LJ, Keys J, Tallack M, Perkins AC, Crossley M., Free PMC Article | 01/21/2010 |
| Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81. | Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81.
Kirberg J, Gschwendner C, Dangy JP, Rückerl F, Frommer F, Bachl J. | 01/21/2010 |