| Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. Results suggest an involvement of RP S19 oligomers in some anxiety-like behavior, especially grooming behavior. | Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice.
Chen J, Kaitsuka T, Fujino R, Araki K, Tomizawa K, Yamamoto T. | 07/29/2017 |
| Rps19 mutant shows behavioural phenotypes resembling that of the human Diamond-Blackfan anaemia syndrome. | Neurological Deficits of an Rps19(Arg67del) Model of Diamond-Blackfan Anaemia.
Kubik-Zahorodna A, Schuster B, Kanchev I, Sedláček R. | 03/4/2017 |
| indicate the importance of the RP S19 oligomer-induced macrophage recruitment in coagulum resorption | Role of blood ribosomal protein S19 in coagulum resorption: a study using Gln137Glu-ribosomal protein S19 gene knock-in mouse.
Chen J, Fujino R, Zhao R, Semba U, Araki K, Yamamoto T. | 08/29/2015 |
| Rps19 mutant embryonic stem cells showed significant increase in p53 protein expression. | p53-Independent cell cycle and erythroid differentiation defects in murine embryonic stem cells haploinsufficient for Diamond Blackfan anemia-proteins: RPS19 versus RPL5.
Singh SA, Goldberg TA, Henson AL, Husain-Krautter S, Nihrane A, Blanc L, Ellis SR, Lipton JM, Liu JM., Free PMC Article | 10/25/2014 |
| We report the generation of mouse models for RPS19-deficient Diamond Blackfan anemia using transgenic RNA interference that allows an inducible and graded down-regulation of Rps19. | Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
Jaako P, Flygare J, Olsson K, Quere R, Ehinger M, Henson A, Ellis S, Schambach A, Baum C, Richter J, Larsson J, Bryder D, Karlsson S. | 01/28/2012 |
| generated a transgenic model expressing an RPS19 mutation in which an arginine residue is replaced with a tryptophan residue at codon 62 as a model of Diamond-Blackfan anemia | A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia.
Devlin EE, Dacosta L, Mohandas N, Elliott G, Bodine DM., Free PMC Article | 11/6/2010 |
| Combined Rps19 insufficiency and Pim-1 deficiency promote murine myeloid cell growth through a deregulation of c-Myc and a simultaneous up-regulation of anti-apoptotic Bcl proteins. | Cooperative effect of ribosomal protein s19 and Pim-1 kinase on murine c-Myc expression and myeloid/erythroid cellularity.
Fröjmark AS, Badhai J, Klar J, Thuveson M, Schuster J, Dahl N. | 03/29/2010 |
| RPS19 significantly compromised CXCR2-dependent MIF-triggered adhesion of monocytes to endothelial cells under flow conditions. We, therefore, propose that RPS19 acts as an extracellular negative regulator of MIF. | Ribosomal protein S19 interacts with macrophage migration inhibitory factor and attenuates its pro-inflammatory function.
Filip AM, Klug J, Cayli S, Fröhlich S, Henke T, Lacher P, Eickhoff R, Bulau P, Linder M, Carlsson-Skwirut C, Leng L, Bucala R, Kraemer S, Bernhagen J, Meinhardt A., Free PMC Article | 01/21/2010 |
| Study reports two mouse dark skin (Dsk) loci caused by mutations in Rps19 (ribosomal protein S19) and Rps20 (ribosomal protein S20). | Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
McGowan KA, Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, de Angelis MH, Myers RM, Attardi LD, Barsh GS., Free PMC Article | 01/21/2010 |
| the loss of one Rps19 allele in mice is fully compensated for at the transcriptional level with preservation of erythropoiesis | Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia.
Matsson H, Davey EJ, Fröjmark AS, Miyake K, Utsugisawa T, Flygare J, Zahou E, Byman I, Landin B, Ronquist G, Karlsson S, Dahl N. | 01/21/2010 |
| Results indicate that ribosomal protein S19 (-/-) zygotes do not form blastocysts, whereas one normal Rps19 allele in mice is sufficient to maintain normal ribosomal and possibly extraribosomal functions. | Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation.
Matsson H, Davey EJ, Draptchinskaia N, Hamaguchi I, Ooka A, Levéen P, Forsberg E, Karlsson S, Dahl N., Free PMC Article | 01/21/2010 |
| presence of an RP S19 dimer- and C5a receptor-mediated autocrine-type augmentation mechanism during Mn II-induced apoptosis in the mouse fibroblastic cell line | S19 ribosomal protein dimer augments metal-induced apoptosis in a mouse fibroblastic cell line by ligation of the C5a receptor.
Nishiura H, Tanase S, Shibuya Y, Futa N, Sakamoto T, Higginbottom A, Monk P, Zwirner J, Yamamoto T. | 01/21/2010 |
| RPS19 mRNA and protein expression were shown to decrease during terminal erythroid differentiation. | Ribosomal protein S19 expression during erythroid differentiation.
Da Costa L, Narla G, Willig TN, Peters LL, Parra M, Fixler J, Tchernia G, Mohandas N. | 01/21/2010 |