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    SREBF1 sterol regulatory element binding transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 6720, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FAS/SREBP-1c contributes to colorectal carcinogenesis through calcium signaling pathway and cAMP signaling pathway.

    FAS/SREBP-1c contributes to colorectal carcinogenesis through calcium signaling pathway and cAMP signaling pathway.
    Xu Y, Hu H, An J, Zong L.

    03/13/2024
    Association of adipocyte size and SREBP-1c in visceral and subcutaneous adipose tissue in non-obese type 2 diabetes mellitus.

    Association of adipocyte size and SREBP-1c in visceral and subcutaneous adipose tissue in non-obese type 2 diabetes mellitus.
    Adhikary P, Banerjee S, Dey BK, Gargari P, Chatterjee S, Chakraborty D, Chowdhury S.

    03/4/2024
    The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.

    The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.
    Chandrasekaran P, Weiskirchen R., Free PMC Article

    02/28/2024
    Expression and correlation analysis of silent information regulator 1 (SIRT1), sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factor in gestational diabetes mellitus.

    Expression and correlation analysis of silent information regulator 1 (SIRT1), sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factor in gestational diabetes mellitus.
    Han N, Chang XY, Yuan ZL, Wang YZ.

    02/14/2024
    EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression.

    EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression.
    Wang Z, Chao Z, Wang Q, Zou F, Song T, Xu L, Ning J, Cheng F., Free PMC Article

    01/30/2024
    Exogenous H2 S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.

    Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
    Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W., Free PMC Article

    01/6/2024
    Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma.

    Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma.
    Jeong DW, Park JW, Kim KS, Kim J, Huh J, Seo J, Kim YL, Cho JY, Lee KW, Fukuda J, Chun YS., Free PMC Article

    11/18/2023
    Recurrent Vascularizing Keratitis in Infants With Hereditary Mucoepithelial Dysplasia Related to SREBF1 Mutation.

    Recurrent Vascularizing Keratitis in Infants With Hereditary Mucoepithelial Dysplasia Related to SREBF1 Mutation.
    Kim S, Jeong H, Ko JM, Kwon O, Oh JY.

    11/13/2023
    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.
    Cho S, Chun Y, He L, Ramirez CB, Ganesh KS, Jeong K, Song J, Cheong JG, Li Z, Choi J, Kim J, Koundouros N, Ding F, Dephoure N, Jang C, Blenis J, Lee G.,

    08/25/2023
    MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.

    MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.
    Zhang S, Zhong J, Guo D, Zhang S, Huang G, Chen Y, Xu C, Chen W, Zhang Q, Zhao C, Liu S, Luo Z, Lin C.

    08/22/2023
    Kruppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1.

    Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1.
    Li X, Zeng X, Kim D, Jiang J, Wei F, Zhang J, Chai B, Fu L, Lee Y, Kim C, Chen H.

    06/7/2023
    Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme Ubiquitin-Specific Protease 14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes.

    Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme Ubiquitin-Specific Protease 14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes.
    Kamoshita K, Ishii KA, Tahira Y, Kikuchi A, Abuduwaili H, Tajima-Shirasaki N, Li Q, Takayama H, Matsumoto K, Takamura T.

    03/23/2023
    TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.

    TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
    Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J., Free PMC Article

    02/4/2023
    Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.

    Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
    Zhu Y, Yang Y, Bu H, Huang H, Chen H, Ran J, Qin L, Ni Y, Yao M, Song T, Li M, Yang Y, Guo T, Chao N, Liu Z, Li W, Zhang L., Free PMC Article

    11/12/2022
    [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].

    [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].
    Jin JH, Zhao BS, Liu YZ.

    06/11/2022
    Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma.

    Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma.
    Luo SD, Tsai HT, Chiu TJ, Li SH, Hsu YL, Su LJ, Tsai MH, Lee CY, Hsiao CC, Chen CH., Free PMC Article

    06/11/2022
    Regulation of Expression of Sterol Regulatory Element-binding Protein 1 in Thyroid Cancer Cells.

    Regulation of Expression of Sterol Regulatory Element-binding Protein 1 in Thyroid Cancer Cells.
    Huang TS, Lee JJ, Huang SY, Cheng SP.

    05/14/2022
    SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway.

    SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway.
    Kuo CY, Chang YC, Chien MN, Jhuang JY, Hsu YC, Huang SY, Cheng SP.

    04/23/2022
    Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis.

    Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis.
    Deng J, Peng M, Zhou S, Xiao D, Hu X, Xu S, Wu J, Yang X., Free PMC Article

    03/26/2022
    Prothymosin alpha promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation.

    Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation.
    Jin L, Zhu LY, Pan YL, Fu HQ, Zhang J.

    01/29/2022
    Induction of SREBP1 degradation coupled with suppression of SREBP1-mediated lipogenesis impacts the response of EGFR mutant NSCLC cells to osimertinib.

    Induction of SREBP1 degradation coupled with suppression of SREBP1-mediated lipogenesis impacts the response of EGFR mutant NSCLC cells to osimertinib.
    Chen Z, Yu D, Owonikoko TK, Ramalingam SS, Sun SY., Free PMC Article

    01/8/2022
    MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway.

    MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway.
    Kanagasabai T, Li G, Shen TH, Gladoun N, Castillo-Martin M, Celada SI, Xie Y, Brown LK, Mark ZA, Ochieng J, Ballard BR, Cordon-Cardo C, Adunyah SE, Jin R, Matusik RJ, Chen Z.

    01/8/2022
    SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer.

    SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer.
    Jin Y, Chen Z, Dong J, Wang B, Fan S, Yang X, Cui M., Free PMC Article

    01/8/2022
    Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.

    Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.
    Liu F, Wei J, Hao Y, Lan J, Li W, Weng J, Li M, Su C, Li B, Mo M, Tang F, Wang Y, Yang Y, Jiao W, Qu S., Free PMC Article

    01/1/2022
    E2F1 promotes proliferation and metastasis of clear cell renal cell carcinoma via activation of SREBP1-dependent fatty acid biosynthesis.

    E2F1 promotes proliferation and metastasis of clear cell renal cell carcinoma via activation of SREBP1-dependent fatty acid biosynthesis.
    Shen D, Gao Y, Huang Q, Xuan Y, Yao Y, Gu L, Huang Y, Zhang Y, Li P, Fan Y, Tang L, Du S, Wu S, Wang H, Wang C, Gong H, Pang Y, Ma X, Wang B, Zhang X.

    12/25/2021
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