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    SECISBP2L SECIS binding protein 2 like [ Homo sapiens (human) ]

    Gene ID: 9728, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SECISBP2Lprovided by HGNC
    Official Full Name
    SECIS binding protein 2 likeprovided by HGNC
    Primary source
    HGNC:HGNC:28997
    See related
    Ensembl:ENSG00000138593 MIM:615756; AllianceGenome:HGNC:28997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLAN; SBP2L
    Summary
    Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 34.5), lung (RPKM 24.8) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    15q21.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (48988638..49046446, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (46796860..46854692, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49280835..49338643, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9380 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49180996-49181177 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49204976-49206175 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:49237854-49239053 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49254590-49255092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:49255093-49255594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9381 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:49267886-49268121 Neighboring gene keratin 8 pseudogene 24 Neighboring gene MPRA-validated peak2330 silencer Neighboring gene MPRA-validated peak2331 silencer Neighboring gene Sharpr-MPRA regulatory region 10237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9384 Neighboring gene RNA, 7SL, cytoplasmic 577, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:49357796-49358296 Neighboring gene uncharacterized LOC124903489 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49447830-49448748 Neighboring gene COP9 signalosome subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression. Donovan J, et al. PLoS One, 2012. PMID 22530054, Free PMC Article
    2. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A. Yu CT, et al. J Thorac Oncol, 2011 Jun. PMID 21566536
    3. Overexpression of Aurora-A bypasses cytokinesis through phosphorylation of suppressed in lung cancer. Chiu SC, et al. Am J Physiol Cell Physiol, 2019 Sep 1. PMID 31314582
    4. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Franke FC, et al. Cell Mol Gastroenterol Hepatol, 2019. PMID 30480076, Free PMC Article
    5. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Tomarev SI, et al. Invest Ophthalmol Vis Sci, 2003 Jun. PMID 12766061

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLAN mediates the Aurora-A-triggered cytokinesis bypass and SLAN plays dual roles in that process depending on its phosphorylation status.
      Title: Overexpression of Aurora-A bypasses cytokinesis through phosphorylation of suppressed in lung cancer.
    2. SECISBP2L (SBP2L) interacts with all known human SECIS RNAs in vitro and selenoprotein mRNAs co-immunoprecipitate with endogenous SBP2L, suggesting a role in regulating selenoprotein expression.
      Title: Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression.
    3. SLAN, also known as KIAA0256. The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A.
      Title: The novel protein suppressed in lung cancer down-regulated in lung cancer tissues retards cell proliferation and inhibits the oncokinase Aurora-A.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0256

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables selenocysteine insertion sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    selenocysteine insertion sequence-binding protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193489.2 → NP_001180418.1  selenocysteine insertion sequence-binding protein 2-like isoform 1

      See identical proteins and their annotated locations for NP_001180418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC008635, BC033001, BM129242, CD678675, D87445
      Consensus CDS
      CCDS53942.1
      UniProtKB/Swiss-Prot
      Q8N767, Q93073
      Related
      ENSP00000453854.1, ENST00000559471.6
      Conserved Domains (1) summary
      pfam01248
      Location:702 → 804
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    2. NM_014701.4 → NP_055516.2  selenocysteine insertion sequence-binding protein 2-like isoform 2

      See identical proteins and their annotated locations for NP_055516.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the CDS compared to variant 1. The resulting isoform (2) is shorter and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      BM129242, CD678675, D87445, DA394911
      Consensus CDS
      CCDS32234.1
      UniProtKB/Swiss-Prot
      Q93073
      Related
      ENSP00000261847.3, ENST00000261847.7
      Conserved Domains (1) summary
      pfam01248
      Location:657 → 759
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      48988638..49046446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      46796860..46854692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93073.3 GenPept UniProtKB/Swiss-Prot:Q93073

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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