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    CCNI cyclin I [ Homo sapiens (human) ]

    Gene ID: 10983, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CCNIprovided by HGNC
    Official Full Name
    cyclin Iprovided by HGNC
    Primary source
    HGNC:HGNC:1595
    See related
    Ensembl:ENSG00000118816 MIM:618783; AllianceGenome:HGNC:1595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYI; CYC1; CCNI1
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 185.4), ovary (RPKM 178.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (77047155..77075989, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (80387967..80416780, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (77968308..77997142, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene septin 11 Neighboring gene thioredoxin pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21633 Neighboring gene uncharacterized LOC105377291 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:77936428-77936960 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:77944028-77944647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15500 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:77997338-77998308 Neighboring gene ribosomal protein L7 pseudogene 17 Neighboring gene ubiquitin family domain containing 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cyclin I is involved in the regulation of cell cycle progression. Nagano T, et al. Cell Cycle, 2013 Aug 15. PMID 23907122, Free PMC Article
    2. Expression of a novel isoform of cyclin I in human testis. Zhu X, et al. Biochem Biophys Res Commun, 1998 Aug 10. PMID 9705831
    3. Cyclin I: a new cyclin encoded by a gene isolated from human brain. Nakamura T, et al. Exp Cell Res, 1995 Dec. PMID 7493655
    4. CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation. Quandt E, et al. Mol Oncol, 2023 Jul. PMID 37081792, Free PMC Article
    5. Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer. Li R, et al. Eur Rev Med Pharmacol Sci, 2015 Dec. PMID 26698249

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
      Title: CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
    2. A cyclin I-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.
      Title: Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer.
    3. Knockdown of Cyclin I induced cell cycle arrest at S/G2/M phases.
      Title: Cyclin I is involved in the regulation of cell cycle progression.
    4. The increased levels of cyclin I and GDI2 found to be associated with pancreatic carcinoma were further confirmed by Western blot analyses in an independent series of serum samples and/or pancreatic juice samples
      Title: Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-I
    Names
    cyclin ITI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348132.2 → NP_001335061.1  cyclin-I isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AC104771, AC111196
      Consensus CDS
      CCDS3580.1
      UniProtKB/Swiss-Prot
      B2R6M0, B7Z6X4, Q14094
      UniProtKB/TrEMBL
      Q6FHH0
      Conserved Domains (1) summary
      pfam00134
      Location:34 → 142
      Cyclin_N; Cyclin, N-terminal domain

    2. NM_001348133.2 → NP_001335062.1  cyclin-I isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AC104771, AC111196
      Consensus CDS
      CCDS3580.1
      UniProtKB/Swiss-Prot
      B2R6M0, B7Z6X4, Q14094
      UniProtKB/TrEMBL
      Q6FHH0
      Conserved Domains (1) summary
      pfam00134
      Location:34 → 142
      Cyclin_N; Cyclin, N-terminal domain

    3. NM_001348134.2 → NP_001335063.1  cyclin-I isoform b

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196
      UniProtKB/TrEMBL
      Q53GK0
      Conserved Domains (1) summary
      cd20526
      Location:30 → 128
      CYCLIN_CCNI-like; cyclin box found in cyclin-I (CCNI) and similar proteins

    4. NM_001348135.2 → NP_001335064.1  cyclin-I isoform c

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196
      UniProtKB/TrEMBL
      Q6FHH0
      Conserved Domains (1) summary
      pfam00134
      Location:28 → 112
      Cyclin_N; Cyclin, N-terminal domain

    5. NM_001348136.2 → NP_001335065.1  cyclin-I isoform d

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196
      UniProtKB/TrEMBL
      Q6FHH0
      Conserved Domains (2) summary
      cl00050
      Location:47 → 99
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl25647
      Location:29 → 171
      Cyclin_N2; N-terminal region of cyclin_N

    6. NM_001348137.2 → NP_001335066.1  cyclin-I isoform e

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196
      UniProtKB/TrEMBL
      Q6FHH0
      Conserved Domains (1) summary
      cl00050
      Location:28 → 88
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    7. NM_001348138.2 → NP_001335067.1  cyclin-I isoform f

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196
      Conserved Domains (1) summary
      cl00050
      Location:1 → 37
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    8. NM_001348139.2 → NP_001335068.1  cyclin-I isoform g

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196

    9. NM_001348140.2 → NP_001335069.1  cyclin-I isoform h

      Status: REVIEWED

      Source sequence(s)
      AC104771, AC111196
      Conserved Domains (1) summary
      pfam00134
      Location:28 → 142
      Cyclin_N; Cyclin, N-terminal domain

    10. NM_006835.3 → NP_006826.1  cyclin-I isoform a

      See identical proteins and their annotated locations for NP_006826.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC104771, AC111196
      Consensus CDS
      CCDS3580.1
      UniProtKB/Swiss-Prot
      B2R6M0, B7Z6X4, Q14094
      UniProtKB/TrEMBL
      Q6FHH0
      Related
      ENSP00000237654.4, ENST00000237654.9
      Conserved Domains (1) summary
      pfam00134
      Location:34 → 142
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      77047155..77075989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      80387967..80416780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14094.1 GenPept UniProtKB/Swiss-Prot:Q14094

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