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    SBK2 SH3 domain binding kinase family member 2 [ Homo sapiens (human) ]

    Gene ID: 646643, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SBK2provided by HGNC
    Official Full Name
    SH3 domain binding kinase family member 2provided by HGNC
    Primary source
    HGNC:HGNC:34416
    See related
    Ensembl:ENSG00000187550 MIM:620414; AllianceGenome:HGNC:34416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGK069
    Summary
    Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade and protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward heart (RPKM 14.0) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55528611..55537133, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58624919..58633076, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56039978..56048500, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15097 Neighboring gene N-acetyltransferase 14 (putative) Neighboring gene scavenger receptor cysteine rich family member with 5 domains Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11040 Neighboring gene Sharpr-MPRA regulatory region 5021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56028273-56028774 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:56032833-56032983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56037524-56038398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56042573-56043073 Neighboring gene Sharpr-MPRA regulatory region 3421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56056311-56057147 Neighboring gene Sharpr-MPRA regulatory region 14522 Neighboring gene SH3 domain binding kinase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56064283-56064783 Neighboring gene zinc finger protein 579

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Patterns of somatic mutation in human cancer genomes. Greenman C, et al. Nature, 2007 Mar 8. PMID 17344846, Free PMC Article
    2. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
    3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
    4. Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. Buljan M, et al. Mol Cell, 2020 Aug 6. PMID 32707033, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SBK2
    Names
    SH3-binding domain kinase family, member 2
    Sugen kinase 69
    NP_001357025.1
    XP_011525529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370096.2 → NP_001357025.1  serine/threonine-protein kinase SBK2

      Status: VALIDATED

      Source sequence(s)
      AC008735
      Consensus CDS
      CCDS42631.1
      UniProtKB/Swiss-Prot
      P0C263
      Related
      ENSP00000389015.2, ENST00000413299.6
      Conserved Domains (1) summary
      cl21453
      Location:68 → 329
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55528611..55537133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527227.3 → XP_011525529.1  serine/threonine-protein kinase SBK2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:68 → 153
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58624919..58633076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001101401.2: Suppressed sequence

      Description
      NM_001101401.2: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C263.2 GenPept UniProtKB/Swiss-Prot:P0C263

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